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Versican (VCAN)

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CSPG2; VS; ERVR; PG-M; WGN1; Chondroitin Sulfate Proteoglycan 2; Chondroitin sulfate proteoglycan core protein 2; Glial hyaluronate-binding; Large fibroblast proteoglycan

Versican (VCAN)
CCC B817
HGNC 2464
MGI 102889
PubMed 12231358
RGD 619940
UniProt P13611
Wiki Versican

Versican is a large chondroitin sulfate proteoglycan with an apparent molecular mass of more than 1000kDa. In 1989, Zimmermann and Ruoslahti cloned and sequenced the core protein of fibroblast chondroitin sulfate proteoglycan. They designated it versican in recognition of its versatile modular structure. Versican belongs to the lectican protein family, with Aggrecan (abundant in Cartilage), Brevican and Neurocan (nervous system proteoglycans) as other members.

Versican is also known as Chondroitin sulfate proteoglycan core protein 2 (CSPG-2), PG-M, and Chondroitin sulfate proteoglycan 2.These proteoglycans share a homologous globular N-terminal, C-terminal, and glycosaminoglycan (GAG) binding regions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB817Hu01 Recombinant Versican (VCAN) Positive Control; Immunogen; SDS-PAGE; WB.
RPB817Hu02 Recombinant Versican (VCAN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB817Hu01 Polyclonal Antibody to Versican (VCAN) WB,IHC
MAB817Hu22 Monoclonal Antibody to Versican (VCAN) WB; IHC; ICC; IP.
PAB817Hu02 Polyclonal Antibody to Versican (VCAN) WB; IHC; ICC; IP.
Assay Kits SEB817Hu ELISA Kit for Versican (VCAN) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB817Hu CLIA Kit for Versican (VCAN) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB817Mu01 Recombinant Versican (VCAN) Positive Control; Immunogen; SDS-PAGE; WB.
RPB817Mu02 Recombinant Versican (VCAN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB817Mu01 Polyclonal Antibody to Versican (VCAN) WB; IHC; ICC; IP.
PAB817Mu02 Polyclonal Antibody to Versican (VCAN) WB; IHC; ICC; IP.
Assay Kits SEB817Mu ELISA Kit for Versican (VCAN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB817Ra01 Recombinant Versican (VCAN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB817Ra01 Polyclonal Antibody to Versican (VCAN) WB; IHC; ICC; IP.
Assay Kits SEB817Ra ELISA Kit for Versican (VCAN) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Multiple domains of the large fibroblast proteoglycan, versican."EMBO J. 8:2975-2981(1989) [PubMed] [Europe PMC] [Abstract]
  2. "A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican."J. Biol. Chem. 269:32992-32998(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter."J. Biol. Chem. 269:32999-33008(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues."J. Biol. Chem. 270:3914-3918(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry."Matrix Biol. 14:213-225(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14)."Genomics 14:845-851(1992) [PubMed] [Europe PMC] [Abstract]
  7. "A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences."J. Biol. Chem. 262:13120-13125(1987) [PubMed] [Europe PMC] [Abstract]
  8. "Versican/PG-M isoforms in vascular smooth muscle cells."Arterioscler. Thromb. Vasc. Biol. 19:1630-1639(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Isolation of a large aggregating proteoglycan from human brain."J. Biol. Chem. 267:23883-23887(1992) [PubMed] [Europe PMC] [Abstract]
  10. "Isolation and partial characterization of a glial hyaluronate-binding protein."J. Biol. Chem. 264:5981-5987(1989) [PubMed] [Europe PMC] [Abstract]
  11. "Structural similarity of hyaluronate binding proteins in brain and cartilage."Brain Res. Bull. 22:67-70(1989) [PubMed] [Europe PMC] [Abstract]
  12. "Differential expression of versican isoforms in brain tumors."J. Neuropathol. Exp. Neurol. 55:528-533(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome."Invest. Ophthalmol. Vis. Sci. 46:2726-2735(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Novel VCAN mutations and evidence for unbalanced alternative splicing in the pathogenesis of Wagner syndrome."Eur. J. Hum. Genet. 21:352-356(2013) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]