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Beta Secretase 2 (BACE2)

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AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP; Beta-Site APP Cleaving Enzyme 2; Aspartic-like protease 56 kDa; Aspartyl protease 1; Down region aspartic protease; Memapsin-1

Beta Secretase 2 (BACE2)
CCC B812
HGNC 934
MGI 1860440
PubMed 15857888
RGD 1303241
UniProt Q9Y5Z0
Wiki BACE2

BACE2 (Beta-site amyloid precursor protein cleaving enzyme 2) is a close homolog of BACE1, a protease known to be an important enzyme involved in the cellular pathways that some believe lead to Alzheimer's disease. The physiological function and role of BACE2 in Alzheimer's disease is unknown. Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB812Hu01 Recombinant Beta Secretase 2 (BACE2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB812Hu01 Polyclonal Antibody to Beta Secretase 2 (BACE2) WB,IHC
LAB812Hu71 Biotin-Linked Polyclonal Antibody to Beta Secretase 2 (BACE2) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Beta Secretase 2 (BACE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta Secretase 2 (BACE2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB812Mu01 Recombinant Beta Secretase 2 (BACE2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB812Mu01 Polyclonal Antibody to Beta Secretase 2 (BACE2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Beta Secretase 2 (BACE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta Secretase 2 (BACE2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB812Ra01 Recombinant Beta Secretase 2 (BACE2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB812Ra01 Polyclonal Antibody to Beta Secretase 2 (BACE2) WB; IHC
LAB812Ra81 FITC-Linked Polyclonal Antibody to Beta Secretase 2 (BACE2) WB; IHC; ICC; IF.
LAB812Ra71 Biotin-Linked Polyclonal Antibody to Beta Secretase 2 (BACE2) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Beta Secretase 2 (BACE2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Beta Secretase 2 (BACE2) ELISA Kit Customized Service Offer
  1. "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity."Nature 402:533-537(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines."Biochim. Biophys. Acta 1501:125-137(2000) [PubMed] [Europe PMC] [Abstract]
  3. "A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase."Cytogenet. Cell Genet. 89:177-184(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region."FEBS Lett. 468:59-64(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Expression analysis of BACE2 in brain and peripheral tissues."J. Biol. Chem. 275:20647-20651(2000) [PubMed] [Europe PMC] [Abstract]
  6. "ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site."Mol. Cell. Neurosci. 16:609-619(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein."Proc. Natl. Acad. Sci. U.S.A. 97:1456-1460(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes."FASEB J. 19:739-749(2005) [PubMed] [Europe PMC] [Abstract]
  13. "BACE2 functions as an alternative alpha-secretase in cells."J. Biol. Chem. 276:34019-34027(2001) [PubMed] [Europe PMC] [Abstract]
  14. "BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome."FASEB J. 20:1369-1376(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor."J. Mol. Biol. 355:249-261(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Prodomain processing of Asp1 (BACE2) is autocatalytic."J. Biol. Chem. 276:23322-23328(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein."Eur. J. Neurosci. 24:1237-1244(2006) [PubMed] [Europe PMC] [Abstract]