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S100 Calcium Binding Protein A8 (S100A8)

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MRP8; MIF; 60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag; NIF; P8; Calgranulin A; Cystic fibrosis antigen; Leukocyte L1 complex light chain; Migration inhibitory factor-related protein 8

S100 Calcium Binding Protein A8 (S100A8)
CCC B792
HGNC 10498
MGI 88244
PubMed 16931866
RGD 620265
UniProt P05109
Wiki S100A8

S100A8, a protein associated with a wide variety of inflammatory conditions, is heavily over-expressed in association with inflammation. Human S100A8 possesses neutrophil-repelling properties that result in an anti-inflammatory effect in vivo. The chemotactic activity of S100A8 on neutrophils was tested in Transwell chemotaxis assays. Analysis of the data indicates that S100A8 causes a repulsion of peripheral neutrophils, an activity that S100A8 loses upon its oxidation. S100A8 causes a strong anti-inflammatory effect in the rat air-pouch model of inflammation in vivo. These data highlight a naturally occurring novel anti-inflammatory pathway and provide potential molecular targets for the development of novel anti-inflammatory therapeutics.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Hu01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
RPB792Hu02 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
APB792Hu01 Active S100 Calcium Binding Protein A8 (S100A8) Cell culture; Activity Assays.
Antibodies PAB792Hu01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC
LAB792Hu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC.
LAB792Hu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IF.
MAB792Hu21 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC
PAB792Hu02 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) IHC; FCM
MAB792Hu24 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; ICC/IF
MAB792Hu22 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC
MAB792Hu23 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC/IF
MAB792Hu25 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) IHC; ICC/IF
MAB792Hu26 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB
MAB792Hu28 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB
MAB792Hu27 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) ICC/IF
MAB792Hu29 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) ICC/IF
Assay Kits SEB792Hu ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Mu01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
RPB792Mu02 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
EPB792Mu61 Eukaryotic S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
APB792Mu61 Active S100 Calcium Binding Protein A8 (S100A8) Cell culture; Activity Assays.
Antibodies PAB792Mu01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC
LAB792Mu71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC.
LAB792Mu81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IF.
PAB792Mu02 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
MAB792Mu21 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB
Assay Kits SEB792Mu ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Ra01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
APB792Ra01 Active S100 Calcium Binding Protein A8 (S100A8) Cell culture; Activity Assays.
Antibodies PAB792Ra01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; ICC/IF
LAB792Ra71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB
LAB792Ra81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IF.
MAB792Ra21 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB
Assay Kits SEB792Ra ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Rb01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB792Rb51 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC
PAB792Rb01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for S100 Calcium Binding Protein A8 (S100A8) CLIA Kit Customized Service Offer
n/a ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Ca01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB792Ca01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC
Assay Kits n/a CLIA Kit for S100 Calcium Binding Protein A8 (S100A8) CLIA Kit Customized Service Offer
n/a ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Po01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB792Po01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC
Assay Kits SEB792Po ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB792Bo01 Recombinant S100 Calcium Binding Protein A8 (S100A8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB792Bo01 Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC
LAB792Bo71 Biotin-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB
LAB792Bo81 FITC-Linked Polyclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IF.
MAB792Bo21 Monoclonal Antibody to S100 Calcium Binding Protein A8 (S100A8) WB; IHC; ICC; IP.
Assay Kits SEB792Bo ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) Enzyme-linked immunosorbent assay for Antigen Detection.
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  24. "S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis."Eur. J. Pharmacol. 625:73-83(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation."FEMS Immunol. Med. Microbiol. 55:55-61(2009) [PubMed] [Europe PMC] [Abstract]
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  41. "The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins."J. Mol. Biol. 370:887-898(2007) [PubMed] [Europe PMC] [Abstract]