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Caspase 4 (CASP4)

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ICE(rel)II; ICH2; TX; Protease ICH-2; Cysteinyl Aspartate Specific Proteinases 4; Apoptosis-Related Cysteine Peptidase

Caspase 4 (CASP4)
CCC B735
HGNC 1505
MGI 107700
PubMed 23684308
RGD 621757
UniProt P49662
Wiki Caspase_4

Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue, and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5, with a role in the immune system.

Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB735Hu01 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB735Hu02 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB735Hu03 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB735Hu01 Polyclonal Antibody to Caspase 4 (CASP4) WB; ICC; IHC-P; IHC-F; ELISA.
MAB735Hu22 Monoclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
PAB735Hu02 Polyclonal Antibody to Caspase 4 (CASP4) WB; ICC; IHC-P; IHC-F; ELISA.
LAB735Hu71 Biotin-Linked Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC.
LAB735Hu81 FITC-Linked Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IF.
Assay Kits SEB735Hu ELISA Kit for Caspase 4 (CASP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB735Mu01 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB735Mu02 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB735Mu01 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
PAB735Mu02 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
LAB735Mu71 Biotin-Linked Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Caspase 4 (CASP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 4 (CASP4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB735Ra01 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB735Ra01 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Caspase 4 (CASP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 4 (CASP4) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB735Bo01 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB735Bo02 Recombinant Caspase 4 (CASP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB735Bo01 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
PAB735Bo02 Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
LAB735Bo71 Biotin-Linked Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC.
LAB735Bo81 FITC-Linked Polyclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IF.
MAB735Bo21 Monoclonal Antibody to Caspase 4 (CASP4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Caspase 4 (CASP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caspase 4 (CASP4) ELISA Kit Customized Service Offer
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  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Transmembrane protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis."J. Biol. Chem. 288:17908-17917(2013) [PubMed] [Europe PMC] [Abstract]
  11. "The E.coli effector protein NleF is a caspase inhibitor."PLoS ONE 0:0-0(2013)