≡

Cluster Of Differentiation (CD163)

[Edit]

M130; MM130; Scavenger receptor cysteine-rich type 1 protein M130; Hemoglobin scavenger receptor

Cluster Of Differentiation (CD163)
CCC B726
HGNC 1631
MGI 2135946
PubMed 15491976
RGD 1310382
UniProt Q86VB7
Wiki CD163

CD163, a hemoglobin scavenger receptor, is expressed in monocytes and macrophages.Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin c by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage.

CD163 may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. It exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB726Hu01 Recombinant Cluster Of Differentiation (CD163) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB726Hu01 Polyclonal Antibody to Cluster Of Differentiation (CD163) WB
MAB726Hu21 Monoclonal Antibody to Cluster Of Differentiation (CD163) WB; IHC; ICC; IP.
Assay Kits SEB726Hu ELISA Kit for Cluster Of Differentiation (CD163) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB726Mu01 Recombinant Cluster Of Differentiation (CD163) Positive Control; Immunogen; SDS-PAGE; WB.
RPB726Mu02 Recombinant Cluster Of Differentiation (CD163) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB726Mu01 Polyclonal Antibody to Cluster Of Differentiation (CD163) WB; IHC
PAB726Mu02 Polyclonal Antibody to Cluster Of Differentiation (CD163) WB; IHC; ICC; IP.
LAB726Mu81 FITC-Linked Polyclonal Antibody to Cluster Of Differentiation (CD163) WB; IHC; ICC; IF.
Assay Kits SEB726Mu ELISA Kit for Cluster Of Differentiation (CD163) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB726Ra01 Recombinant Cluster Of Differentiation (CD163) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB726Ra01 Polyclonal Antibody to Cluster Of Differentiation (CD163) IHC
MAB726Ra21 Monoclonal Antibody to Cluster Of Differentiation (CD163) WB; IHC
MAB726Ra22 Monoclonal Antibody to Cluster Of Differentiation (CD163) WB
MAB726Ra23 Monoclonal Antibody to Cluster Of Differentiation (CD163) WB; IHC
MAB726Ra24 Monoclonal Antibody to Cluster Of Differentiation (CD163) WB
MAB726Ra25 Monoclonal Antibody to Cluster Of Differentiation (CD163) WB; IHC
MAB726Ra27 Monoclonal Antibody to Cluster Of Differentiation (CD163) WB
MAB726Ra28 Monoclonal Antibody to Cluster Of Differentiation (CD163) IHC
MAB726Ra26 Monoclonal Antibody to Cluster Of Differentiation (CD163) WB
Assay Kits SEB726Ra ELISA Kit for Cluster Of Differentiation (CD163) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily."Eur. J. Immunol. 23:2320-2325(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and chromosomal localization of the human CD163 (M130) gene: a member of the scavenger receptor cysteine-rich superfamily."Biochem. Biophys. Res. Commun. 260:466-474(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family."Biochem. Biophys. Res. Commun. 256:110-113(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of CD 163 on human macrophages: cross-linking of CD163 induces signaling and activation."J. Leukoc. Biol. 66:858-866(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli."J. Leukoc. Biol. 67:97-103(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C."Eur. J. Immunol. 31:999-1009(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of the haemoglobin scavenger receptor."Nature 409:198-201(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP-3."Clin. Exp. Immunol. 130:156-161(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Only the soluble form of the scavenger receptor CD163 acts inhibitory on phorbol ester-activated T-lymphocytes, whereas membrane-bound protein has no effect."FEBS Lett. 526:93-96(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163."J. Leukoc. Biol. 72:711-717(2002) [PubMed] [Europe PMC] [Abstract]
  13. "CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response."Ann. Med. 36:347-354(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region."J. Biol. Chem. 279:51561-51567(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Cross-linking of FcgammaR triggers shedding of the hemoglobin-haptoglobin scavenger receptor CD163."J. Leukoc. Biol. 76:271-277(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  17. "The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants."J. Leukoc. Biol. 79:837-845(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  19. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]