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Pyridoxal Kinase (PDXK)

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PKH; PNK; C21orf124; C21orf97; PRED79; Pyridoxine Kinase; Vitamin B6 Kinase

Pyridoxal Kinase (PDXK)
CCC B724
HGNC 8819
MGI 1351869
PubMed 16740960
RGD 621324
UniProt O00764
Wiki PDXK

Pyridoxal (pyridoxine, vitamin B6) kinase is also known as PDXK. The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Hanna et al. (1997) cloned the cDNA encoding PDXK, which they referred to as PKH. The PDXK gene encodes a 312-amino acid polypeptide, and expression of the cDNA revealed pyridoxal kinase activity. Northern blot analysis revealed that a major 1.5-kb PDXK transcript was expressed in all tissues tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB724Hu01 Recombinant Pyridoxal Kinase (PDXK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB724Hu01 Polyclonal Antibody to Pyridoxal Kinase (PDXK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Pyridoxal Kinase (PDXK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyridoxal Kinase (PDXK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB724Mu01 Recombinant Pyridoxal Kinase (PDXK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB724Mu01 Polyclonal Antibody to Pyridoxal Kinase (PDXK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Pyridoxal Kinase (PDXK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyridoxal Kinase (PDXK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB724Ra01 Recombinant Pyridoxal Kinase (PDXK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB724Ra01 Polyclonal Antibody to Pyridoxal Kinase (PDXK) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Pyridoxal Kinase (PDXK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyridoxal Kinase (PDXK) ELISA Kit Customized Service Offer
  1. "Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor."J. Biol. Chem. 272:10756-10760(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of a novel pyridoxal kinase mRNA splice variant, PKH-T, in human testis."Asian J. Androl. 6:83-91(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human pyridoxal kinase: overexpression and properties of the recombinant enzyme."Mol. Cells 10:452-459(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]