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Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1)

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SQS; SS; Squalene Synthase; FPP farnesyltransferase

Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1)
CCC B708
HGNC 3629
MGI 102706
PubMed 8020937
RGD 61834
UniProt P37268
Wiki SQS

Farnesyl-diphosphate farnesyltransferase (FDFT1) is an enzyme that converts two units of farnesyl pyrophosphate into squalene.It has been described as the first dedicated enzyme of sterol (i.e., cholesterol, etc.) synthesis, since the squalene formed by it is exclusively routed into various sterols via a complex, multi-step pathway.Squalene synthase is considered to be an enzyme of eukaryotes or advanced organisms, although at least one prokaryote has been shown to possess a functionally similar enzyme.

In terms of structure and mechanics, squalene synthase most closely resembles phytoene syntase, which serves a similar role in many plants in the elaboration of phytoene, a precursor of many carotenoid compounds.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB708Hu01 Recombinant Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB708Hu01 Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) WB; IHC; ICC; IP.
MAB708Hu22 Monoclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB708Mu01 Recombinant Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB708Mu01 Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) WB; IHC; ICC; IP.
LAB708Mu81 FITC-Linked Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) WB; IHC; ICC; IF.
LAB708Mu71 Biotin-Linked Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB708Ra01 Recombinant Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB708Ra01 Polyclonal Antibody to Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Farnesyl Diphosphate Farnesyltransferase 1 (FDFT1) ELISA Kit Customized Service Offer
  1. "Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation."Mol. Cell. Biol. 13:2706-2717(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase."J. Biol. Chem. 268:12818-12824(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, expression and characterisation of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase."Gene 136:185-192(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems."Arch. Biochem. Biophys. 316:713-723(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis."J. Biol. Chem. 275:30610-30617(2000) [PubMed] [Europe PMC] [Abstract]
  11. "K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population."Hum. Mutat. 29:689-694(2008) [PubMed] [Europe PMC] [Abstract]