≡

Myeloid Differentiation Factor 88 (MyD88)

[Edit]

Myeloid Differentiation Primary Response Gene 88

Myeloid Differentiation Factor 88 (MyD88)
CCC B707
HGNC 7562
MGI 108005
PubMed 9697844
RGD 735043
UniProt Q99836
Wiki MyD88

Myeloid differentiation factor 88 (MyD88) is a key adaptor protein that MyD88 is a common adaptor molecule required for signaling mediated by TLRs. When the receptors are activated, cells bearing TLRs produce various proinflammatory cytokines in a MyD88-dependent manner. Liver regeneration following partial hepatectomy (PH) requires innate immune responses, particularly interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) production by Kupffer cells, although the recognition and activation processes are still unknown. However, TLR2, 4 and 9, which recognize gram-negative and -positive bacterial products, are not essential for NF-kappaB activation and IL-6 production after PH, which excludes a possible contribution of TLR2/TLR4 or TLR9 to MyD88-mediated pathways.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB707Hu01 Recombinant Myeloid Differentiation Factor 88 (MyD88) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB707Hu01 Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) WB; IHC; ICC; IP.
MAB707Hu22 Monoclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) WB; IHC; ICC; IP.
Assay Kits SEB707Hu ELISA Kit for Myeloid Differentiation Factor 88 (MyD88) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB707Mu01 Recombinant Myeloid Differentiation Factor 88 (MyD88) Positive Control; Immunogen; SDS-PAGE; WB.
RPB707Mu02 Recombinant Myeloid Differentiation Factor 88 (MyD88) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB707Mu01 Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) WB; IHC; ICC; IP.
PAB707Mu02 Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) WB; IHC; ICC; IP.
Assay Kits SEB707Mu ELISA Kit for Myeloid Differentiation Factor 88 (MyD88) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB707Ra01 Recombinant Myeloid Differentiation Factor 88 (MyD88) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB707Ra01 Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) WB; IHC; ICC; IP.
MAB707Ra21 Monoclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) WB; IHC; ICC; IP.
Assay Kits SEB707Ra ELISA Kit for Myeloid Differentiation Factor 88 (MyD88) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB707Ga01 Recombinant Myeloid Differentiation Factor 88 (MyD88) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB707Ga01 Polyclonal Antibody to Myeloid Differentiation Factor 88 (MyD88) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Myeloid Differentiation Factor 88 (MyD88) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myeloid Differentiation Factor 88 (MyD88) ELISA Kit Customized Service Offer
  1. "Molecular characterization and modular analysis of human MyD88."Oncogene 13:2467-2475(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family."FEBS Lett. 402:81-84(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Natural selection in the TLR-related genes in the course of primate evolution."Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6."Nat. Immunol. 5:1061-1068(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling."Proc. Natl. Acad. Sci. U.S.A. 101:15416-15421(2004) [PubMed] [Europe PMC] [Abstract]
  9. "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines."Immunity 23:479-490(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1."Nat. Immunol. 7:1057-1065(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways."J. Immunol. 180:3485-3491(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins."J. Immunol. 182:3450-3460(2009) [PubMed] [Europe PMC] [Abstract]
  13. "AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling."J. Biol. Chem. 285:3750-3757(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly."J. Biol. Chem. 286:1341-1353(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Oncogenically active MYD88 mutations in human lymphoma." Nature 470:115-119(2011) [PubMed] [Europe PMC] [Abstract]
  16. "IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex."Cell Rep. 3:724-733(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Functional assessment of the mutational effects of human IRAK4 and MyD88 genes."Mol. Immunol. 58:66-76(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling."Proc. Natl. Acad. Sci. U.S.A. 106:10260-10265(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Solution NMR structure of human myeloid differentiation primary response (MYD88)."Submitted (FEB-2009) to the PDB data bank
  20. "Pyogenic bacterial infections in humans with MyD88 deficiency." Science 321:691-696(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency." Medicine (Baltimore) 89:403-425(2010) [PubMed] [Europe PMC] [Abstract]
  22. "MYD88 L265P somatic mutation in Waldenstrom's macroglobulinemia."N. Engl. J. Med. 367:826-833(2012) [PubMed] [Europe PMC] [Abstract]