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Cytokeratin 10 (CK10)

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K10; KRT10; KPP; Keratin 10; Epidermolytic Hyperkeratosis; Keratosis Palmaris Et Plantaris; Keratin, type I cytoskeletal 10

Cytokeratin 10 (CK10)
CCC B691
HGNC 6413
MGI 96685
PubMed 15482487
RGD 1359092
UniProt P13645
Wiki Keratin_10

Keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris), also known as KRT10, is a human gene.This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins.

Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB691Hu01 Recombinant Cytokeratin 10 (CK10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB691Hu01 Polyclonal Antibody to Cytokeratin 10 (CK10) WB; IHC; ICC; IP.
MAB691Hu22 Monoclonal Antibody to Cytokeratin 10 (CK10) WB; IHC; ICC; IP.
MAB691Hu27 Monoclonal Antibody to Cytokeratin 10 (CK10) WB; IHC; ICC; IP.
MAB691Hu23 Monoclonal Antibody to Cytokeratin 10 (CK10) WB; IHC; ICC; IP.
MAB691Hu24 Monoclonal Antibody to Cytokeratin 10 (CK10) WB; IHC; ICC; IP.
MAB691Hu25 Monoclonal Antibody to Cytokeratin 10 (CK10) WB; IHC; ICC; IP.
MAB691Hu21 Monoclonal Antibody to Cytokeratin 10 (CK10) WB; IHC; ICC; IP.
MAB691Hu29 Monoclonal Antibody to Cytokeratin 10 (CK10) WB; IHC; ICC; IP.
Assay Kits SEB691Hu ELISA Kit for Cytokeratin 10 (CK10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB691Mu01 Recombinant Cytokeratin 10 (CK10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cytokeratin 10 (CK10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytokeratin 10 (CK10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytokeratin 10 (CK10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 10 (CK10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB691Ra01 Recombinant Cytokeratin 10 (CK10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB691Ra01 Polyclonal Antibody to Cytokeratin 10 (CK10) WB; IHC; ICC; IP.
LAB691Ra71 Biotin-Linked Polyclonal Antibody to Cytokeratin 10 (CK10) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cytokeratin 10 (CK10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 10 (CK10) ELISA Kit Customized Service Offer
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  7. "Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats."Gene 116:245-251(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10."Science 330:94-97(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes."Cell 70:811-819(1992) [PubMed] [Europe PMC] [Abstract]
  14. "Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops."Proc. Natl. Acad. Sci. U.S.A. 89:910-914(1992) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis."Science 257:1128-1130(1992) [PubMed] [Europe PMC] [Abstract]
  16. "Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis."Am. J. Hum. Genet. 54:179-190(1994) [PubMed] [Europe PMC] [Abstract]
  17. "Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity."J. Clin. Invest. 93:1533-1542(1994) [PubMed] [Europe PMC] [Abstract]
  18. "Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE)."J. Invest. Dermatol. 102:24-30(1994) [PubMed] [Europe PMC] [Abstract]
  19. "Genetic and clinical mosaicism in a type of epidermal nevus."N. Engl. J. Med. 331:1408-1415(1994) [PubMed] [Europe PMC] [Abstract]
  20. "A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma."J. Invest. Dermatol. 108:357-361(1997) [PubMed] [Europe PMC] [Abstract]
  21. "A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma."J. Invest. Dermatol. 111:1220-1223(1998) [PubMed] [Europe PMC] [Abstract]
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  23. "Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis."Br. J. Dermatol. 164:442-447(2011) [PubMed] [Europe PMC] [Abstract]