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Interleukin-28 (IL-28) is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses, including the induction an "antiviral state" by turning on Mx proteins, 2',5'-oligoadenylate synthetase as well as ISGF3G (Interferon Stimulated Gene Factor 3). IL-28A and IL-28B belong to the type III interferon family of cytokines and are highly similar (in amino acid sequence) to IL-29.
Interleukin-28A (IL-28A) is a novel cytokine discovered in recent years and has been shown to have antiviral activity. IL-28A, IL-28B and IL-29 are a family of class II cytokines that stimulate antiviral responses through a heterodimeric receptor that is distinct from the type I interferon (IFN) receptor.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB689Hu01 | Recombinant Interleukin 28A (IL28A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB689Hu01 | Active Interleukin 28A (IL28A) | Cell culture; Activity Assays. | |
| Antibodies | PAB689Hu01 | Polyclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. |
| MAB689Hu22 | Monoclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. | |
| MAB689Hu21 | Monoclonal Antibody to Interleukin 28A (IL28A) | WB,IHC | |
| MAB689Hu24 | Monoclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. | |
| MAB689Hu26 | Monoclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. | |
| LAB689Hu76 | Biotin-Linked Monoclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC. | |
| Assay Kits | SEB689Hu | ELISA Kit for Interleukin 28A (IL28A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB689Hu | CLIA Kit for Interleukin 28A (IL28A) | Chemiluminescent immunoassay for Antigen Detection. | |
| HEB689Hu | High Sensitive ELISA Kit for Interleukin 28A (IL28A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB689Mu01 | Recombinant Interleukin 28A (IL28A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB689Mu02 | Recombinant Interleukin 28A (IL28A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPB689Mu61 | Eukaryotic Interleukin 28A (IL28A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APB689Mu61 | Active Interleukin 28A (IL28A) | Cell culture; Activity Assays. | |
| Antibodies | PAB689Mu01 | Polyclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. |
| PAB689Mu02 | Polyclonal Antibody to Interleukin 28A (IL28A) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB689Mu | ELISA Kit for Interleukin 28A (IL28A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB689Mu | CLIA Kit for Interleukin 28A (IL28A) | Chemiluminescent immunoassay for Antigen Detection. |
- "IL-28, IL-29 and their class II cytokine receptor IL-28R." Nat. Immunol. 4:63-68(2003) [PubMed] [Europe PMC] [Abstract]
- "Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication."Virol. J. 2:80-80(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
- "Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells."Acta Pharmacol. Sin. 27:453-459(2006) [PubMed] [Europe PMC] [Abstract]
- "Interferon-lambda: a new addition to an old family."J. Interferon Cytokine Res. 30:555-564(2010) [PubMed] [Europe PMC] [Abstract]
- "Interferon-lambda in the context of viral infections: production, response and therapeutic implications."J. Innate Immun. 6:563-574(2014) [PubMed] [Europe PMC] [Abstract]