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Prostaglandin D2 Synthase (PTGDS)

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HPGDS; GSTS; H-PGDS; PDS; PGD2; PGDS; PGDS2; Glutathione S-Transferase Sigma; Glutathione-requiring prostaglandin D synthase; Prostaglandin D2 Synthase, Hematopoietic

Prostaglandin D2 Synthase (PTGDS)
CCC B640
HGNC 17890
MGI 1859384
PubMed 22370065
RGD 69251
UniProt O60760
Wiki PTGDS

Prostaglandin D synthase catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2).

Prostaglandin D synthase induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGD synthase have been identified, namely the lipocalin type enzyme (b-trace) and the hematopoietic enzyme. Lipocalin type prostaglandin D synthase is localized in the central nervous system and male genital organs of various mammals and the human heart. This enzyme has been identified as b-trace, which is a major protein in human cerebrospinal fluid. Hematopoietic prostaglandin D synthase is widely distributed in the peripheral tissues and is localized in the antigen-presenting cells, mast cells, and megakaryocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB640Hu01 Recombinant Prostaglandin D2 Synthase (PTGDS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB640Hu01 Polyclonal Antibody to Prostaglandin D2 Synthase (PTGDS) WB; IHC; ICC; IP.
MAB640Hu22 Monoclonal Antibody to Prostaglandin D2 Synthase (PTGDS) WB; IHC; ICC; IP.
Assay Kits SEB640Hu ELISA Kit for Prostaglandin D2 Synthase (PTGDS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB640Mu01 Recombinant Prostaglandin D2 Synthase (PTGDS) Positive Control; Immunogen; SDS-PAGE; WB.
RPB640Mu02 Recombinant Prostaglandin D2 Synthase (PTGDS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB640Mu01 Polyclonal Antibody to Prostaglandin D2 Synthase (PTGDS) WB; IHC; ICC; IP.
PAB640Mu02 Polyclonal Antibody to Prostaglandin D2 Synthase (PTGDS) WB; IHC; ICC; IP.
Assay Kits SEB640Mu ELISA Kit for Prostaglandin D2 Synthase (PTGDS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB640Ra01 Recombinant Prostaglandin D2 Synthase (PTGDS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Prostaglandin D2 Synthase (PTGDS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostaglandin D2 Synthase (PTGDS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostaglandin D2 Synthase (PTGDS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin D2 Synthase (PTGDS) ELISA Kit Customized Service Offer
  1. "Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase."Eur. J. Biochem. 267:3315-3322(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases."Biochem. J. 359:507-516(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester."Biochem. Biophys. Res. Commun. 241:288-293(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Prostaglandin D synthase in human megakaryoblastic cells."J. Biol. Chem. 272:28263-28266(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Mechanism of metal activation of human hematopoietic prostaglandin D synthase."Nat. Struct. Biol. 10:291-296(2003) [PubMed] [Europe PMC] [Abstract]
  8. "First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase."J. Biochem. 135:279-283(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase."J. Biol. Chem. 281:15277-15286(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Novel prostaglandin D synthase inhibitors generated by fragment-based drug design."J. Med. Chem. 51:2178-2186(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase."Eur. J. Med. Chem. 45:447-454(2010) [PubMed] [Europe PMC] [Abstract]