Granulocyte Chemotactic Protein 2 (GCP2)
[Edit]CXCL6; SCYB6; GCP2; CKA-3; Chemokine(C-X-C-Motif)ligand 6; Small Inducible Cytokine Subfamily B(Cys-X-Cys)Member 6; Chemokine alpha 3; Small-inducible cytokine B6
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Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.
The GCP2 gene encodes a propeptide of 114 amino acids. Despite 85% identity of the first 270 nucleotides 5-prime of the transcription start sites, GCP2 and the other CXC chemokine gene ENA78 showed cell-specific differences in regulation.In vivo studies in rabbit demonstrated that GCP2 is a potent inflammatory mediator.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB570Hu01 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB570Hu01 | Active Granulocyte Chemotactic Protein 2 (GCP2) | Cell culture; Activity Assays. | |
| Antibodies | PAB570Hu01 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. |
| MAB570Hu22 | Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. | |
| LAB570Hu71 | Biotin-Linked Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC. | |
| LAB570Hu81 | FITC-Linked Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IF. | |
| Assay Kits | SEB570Hu | ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB570Hu | CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB570Mu01 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB570Mu02 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB570Mu01 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. |
| PAB570Mu02 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB570Mu | ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB570Mu | CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB570Ra01 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB570Ra01 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. |
| MAB570Ra21 | Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB570Ra | ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB570Ra | CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB570Bo01 | Recombinant Granulocyte Chemotactic Protein 2 (GCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB570Bo01 | Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2) | ELISA Kit Customized Service Offer |
- "Cloning and characterization of the human granulocyte chemotactic protein-2 gene."J. Immunol. 158:5257-5266(1997) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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- "The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial."Antimicrob. Agents Chemother. 52:2599-2607(2008) [PubMed] [Europe PMC] [Abstract]