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Interferon Regulatory Factor 1 (IRF1)

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Interferon Regulatory Factor 1 (IRF1)
CCC B564
HGNC 6116
MGI 96590
PubMed 24464131
RGD 2920
UniProt P10914
Wiki IRF1

IRF1 is a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppression.IRF1 is highly regulated in human vascular lesions and exhibits a growth inhibitory function in coronary artery smooth muscle cells. Irf1-deficient mice displayed a high grade of susceptibility toward neointima formation following vessel injury. IRF1 led to G1 cell cycle arrest in coronary artery smooth muscle cells and induced the CDK inhibitor p21 (CDKN1A).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB564Hu01 Recombinant Interferon Regulatory Factor 1 (IRF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB564Hu01 Polyclonal Antibody to Interferon Regulatory Factor 1 (IRF1) WB; IHC; ICC; IP.
MAB564Hu22 Monoclonal Antibody to Interferon Regulatory Factor 1 (IRF1) WB; IHC; ICC; IP.
LAB564Hu81 FITC-Linked Polyclonal Antibody to Interferon Regulatory Factor 1 (IRF1) WB; IHC; ICC; IF.
LAB564Hu71 Biotin-Linked Polyclonal Antibody to Interferon Regulatory Factor 1 (IRF1) WB; IHC; ICC.
Assay Kits SEB564Hu ELISA Kit for Interferon Regulatory Factor 1 (IRF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB564Mu01 Recombinant Interferon Regulatory Factor 1 (IRF1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB564Mu02 Recombinant Interferon Regulatory Factor 1 (IRF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB564Mu01 Polyclonal Antibody to Interferon Regulatory Factor 1 (IRF1) WB; IHC; ICC; IP.
LAB564Mu81 FITC-Linked Polyclonal Antibody to Interferon Regulatory Factor 1 (IRF1) WB; IHC; ICC; IF.
LAB564Mu71 Biotin-Linked Polyclonal Antibody to Interferon Regulatory Factor 1 (IRF1) WB; IHC; ICC.
PAB564Mu02 Polyclonal Antibody to Interferon Regulatory Factor 1 (IRF1) WB; IHC; ICC; IP.
Assay Kits SEB564Mu ELISA Kit for Interferon Regulatory Factor 1 (IRF1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB564Ra01 Recombinant Interferon Regulatory Factor 1 (IRF1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 1 (IRF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 1 (IRF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 1 (IRF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 1 (IRF1) ELISA Kit Customized Service Offer
  1. "Sequence of a cDNA coding for human IRF-1."Nucleic Acids Res. 17:3292-3292(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements."Cell 54:903-913(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Human interferon regulatory factor 1: intron-exon organization."DNA Cell Biol. 11:605-611(1992) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia."Science 259:968-971(1993) [PubMed] [Europe PMC] [Abstract]
  6. "A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity."Mol. Cell. Biochem. 191:169-180(1999) [PubMed] [Europe PMC] [Abstract]
  7. "IRF family of transcription factors as regulators of host defense."Annu. Rev. Immunol. 19:623-655(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Activities of IRF-1."J. Interferon Cytokine Res. 22:5-14(2002) [PubMed] [Europe PMC] [Abstract]
  9. "IRF-1 as a negative regulator of cell proliferation."J. Interferon Cytokine Res. 22:39-47(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells."Mol. Cell. Biol. 24:6298-6310(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53."Mol. Cell. Biol. 24:10083-10098(2004) [PubMed] [Europe PMC] [Abstract]
  12. "IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors."Nat. Rev. Immunol. 6:644-658(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression."J. Cell. Physiol. 213:502-510(2007) [PubMed] [Europe PMC] [Abstract]
  14. "RNA interference of interferon regulatory factor-1 gene expression in THP-1 cell line leads to Toll-like receptor-4 overexpression/activation as well as up-modulation of annexin-II."Neoplasia 9:1012-1020(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis."Proc. Natl. Acad. Sci. U.S.A. 104:17028-17033(2007) [PubMed] [Europe PMC] [Abstract]
  16. "IRF-1 promotes apoptosis in p53-damaged basal-type human mammary epithelial cells: a model for early basal-type mammary carcinogenesis."Adv. Exp. Med. Biol. 617:367-374(2008) [PubMed] [Europe PMC] [Abstract]
  17. "IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression."J. Immunol. 181:1673-1682(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Type I interferons and interferon regulatory factors regulate TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected macrophages."PLoS ONE 4:E5397-E5397(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Regulation of immunity and oncogenesis by the IRF transcription factor family."Cancer Immunol. Immunother. 59:489-510(2010) [PubMed] [Europe PMC] [Abstract]
  20. "IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells."Cell Death Differ. 17:699-709(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Human papillomavirus type 16 E5 protein induces expression of beta interferon through interferon regulatory factor 1 in human keratinocytes."J. Virol. 85:5070-5080(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Interferon regulatory factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells."Cancer Lett. 319:56-65(2012) [PubMed] [Europe PMC] [Abstract]
  23. "Interferon regulatory factor 1 transactivates the expression of human DNA polymerase eta in response to the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine."J. Biol. Chem. 287:12622-12633(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer."Int. J. Cancer 77:522-527(1998) [PubMed] [Europe PMC] [Abstract]
  25. "Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding."Biochim. Biophys. Acta 1446:140-144(1999) [PubMed] [Europe PMC] [Abstract]