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Gamma-cystathionase (CTH)

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CSE; Cystathionase; Cysteine-protein sulfhydrase; Gamma-cystathionase

Gamma-cystathionase (CTH)
CCC B538
HGNC 2501
MGI 1339968
PubMed 1789005
RGD 2443
UniProt P32929
Wiki CSE

CSE is an enzyme which breaks down cystathionine into cysteine and alpha-ketobutyrate. Pyridoxal phosphate is a prosthetic group of this enzyme.The bioavailability of cysteine is rate-limiting for the hepatic synthesis of glutathione. Cysteine is provided through either the diet or the transsulfuration pathway, in which cystathionine derived from methionine is transformed into cysteine by cystathionine gamma-lyase.Mutant mice lacking CTH displayed pronounced hypertension and diminished endothelium-dependent vasorelaxation. Cystathionine was physiologically activated by calcium and calmodulin , which is a mechanism for H2S formation in response to vascular activation. Yang et al. (2008) concluded that their findings provided direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB538Hu01 Recombinant Gamma-cystathionase (CTH) Positive Control; Immunogen; SDS-PAGE; WB.
RPB538Hu02 Recombinant Gamma-cystathionase (CTH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB538Hu01 Polyclonal Antibody to Gamma-cystathionase (CTH) WB; IHC
MAB538Hu22 Monoclonal Antibody to Gamma-cystathionase (CTH) WB; IHC; ICC; IP.
Assay Kits SEB538Hu ELISA Kit for Gamma-cystathionase (CTH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB538Mu01 Recombinant Gamma-cystathionase (CTH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB538Mu01 Polyclonal Antibody to Gamma-cystathionase (CTH) WB; IHC; ICC; IP.
Assay Kits SEB538Mu ELISA Kit for Gamma-cystathionase (CTH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB538Ra01 Recombinant Gamma-cystathionase (CTH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB538Ra01 Polyclonal Antibody to Gamma-cystathionase (CTH) WB; IHC; ICC; IP.
MAB538Ra21 Monoclonal Antibody to Gamma-cystathionase (CTH) WB; IHC; ICC; IP.
Assay Kits SEB538Ra ELISA Kit for Gamma-cystathionase (CTH) Enzyme-linked immunosorbent assay for Antigen Detection.
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  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S."J. Biol. Chem. 284:3076-3085(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)."Hum. Genet. 112:404-408(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase."Biochemistry 47:6226-6232(2008) [PubMed] [Europe PMC] [Abstract]