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Neuronal Apoptosis Inhibitory Protein (NAIP)

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BIRC1; NLRB1; PsiNAIP; NLR Family,Apoptosis Inhibitory Protein; Baculoviral IAP Repeat-Containing Protein 1

Neuronal Apoptosis Inhibitory Protein (NAIP)
CCC B524
HGNC 7634
MGI 1298223
PubMed 7813013
UniProt Q13075
Wiki NAIP
The neuronal apoptosis inhibitory protein (NAIP) was identified as a candidate gene for the inherited neurodegenerative disorder spinal muscular atrophy. NAIP is the founding member of a human protein family that is characterized by highly conserved N-terminal motifs called baculovirus inhibitor of apoptosis repeats (BIR). Five members of the human family of inhibitor of apoptosis proteins including NAIP have been shown to be antiapoptotic in various systems. To date, a mechanism for the antiapoptotic effect of NAIP has not been elucidated.Baculoviral IAP repeat-containing protein 1 is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB524Hu01 Recombinant Neuronal Apoptosis Inhibitory Protein (NAIP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB524Hu01 Polyclonal Antibody to Neuronal Apoptosis Inhibitory Protein (NAIP) WB; IHC; ICC; IP.
MAB524Hu22 Monoclonal Antibody to Neuronal Apoptosis Inhibitory Protein (NAIP) WB; IHC; ICC; IP.
Assay Kits SEB524Hu ELISA Kit for Neuronal Apoptosis Inhibitory Protein (NAIP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB524Mu01 Recombinant Neuronal Apoptosis Inhibitory Protein (NAIP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB524Mu01 Polyclonal Antibody to Neuronal Apoptosis Inhibitory Protein (NAIP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Neuronal Apoptosis Inhibitory Protein (NAIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neuronal Apoptosis Inhibitory Protein (NAIP) ELISA Kit Customized Service Offer
  1. "The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy." Cell 80:167-178(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP."Genomics 48:121-127(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes."Biochim. Biophys. Acta 1574:35-50(2002) [PubMed] [Europe PMC] [Abstract]
  6. "A provisional transcript map of the spinal muscular atrophy (SMA) critical region."Eur. J. Hum. Genet. 3:87-95(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes."Nature 379:349-353(1996) [PubMed] [Europe PMC] [Abstract]
  8. "The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7."J. Neurosci. 22:2035-2043(2002) [PubMed] [Europe PMC] [Abstract]
  9. "IAPs: more than just inhibitors of apoptosis proteins."Cell Cycle 7:1036-1046(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP."Biochem. Biophys. Res. Commun. 407:158-162(2011) [PubMed] [Europe PMC] [Abstract]
  11. "The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus."Nature 477:596-600(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila."Microbes Infect. 14:1123-1132(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Structures of BIR domains from human NAIP and cIAP2."Acta Crystallogr. F 65:1091-1096(2009) [PubMed] [Europe PMC] [Abstract]