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Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B)

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CD120B; P75; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR2; TNFR80; P75tnfr; Tumor necrosis factor receptor 2; p80 TNF-alpha receptor; Etanercept

Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B)
CCC B504
HGNC 11917
MGI 1314883
PubMed 11357933
RGD 621238
UniProt P20333
Wiki TNFRSF1B

TNFRSF1B is a human gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB504Hu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Positive Control; Immunogen; SDS-PAGE; WB.
APB504Hu01 Active Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Cell culture; Activity Assays.
EPB504Hu61 Eukaryotic Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB504Hu01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) WB; IHC; ICC; IP.
MAB504Hu21 Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) WB; IHC; ICC; IP.
Assay Kits SEB504Hu ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB504Mu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Positive Control; Immunogen; SDS-PAGE; WB.
EPB504Mu61 Eukaryotic Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Positive Control; Immunogen; SDS-PAGE; WB.
APB504Mu61 Active Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Cell culture; Activity Assays.
Antibodies PAB504Mu01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) WB; IHC; ICC; IP.
LAB504Mu71 Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB504Ra01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Positive Control; Immunogen; SDS-PAGE; WB.
EPB504Ra61 Eukaryotic Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Positive Control; Immunogen; SDS-PAGE; WB.
APB504Ra61 Active Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Cell culture; Activity Assays.
Antibodies PAB504Ra01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) WB; IHC; ICC; IP.
MAB504Ra21 Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) WB; IHC; ICC; IP.
Assay Kits SEB504Ra ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor."Proc. Natl. Acad. Sci. U.S.A. 87:8331-8335(1990) [PubMed] [Europe PMC] [Abstract]
  2. "A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins."Science 248:1019-1023(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Physical mapping and genomic structure of the human TNFR2 gene."Genomics 35:94-100(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2."Int. Immunol. 16:169-177(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells."J. Biol. Chem. 265:20131-20138(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Purification of two types of TNF inhibitors in the urine of the patient with chronic glomerulonephritis."Nephron 66:386-390(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors."J. Biol. Chem. 265:1531-1536(1990) [PubMed] [Europe PMC] [Abstract]
  10. "Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences."Cytokine 2:231-237(1990) [PubMed] [Europe PMC] [Abstract]
  11. "Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor."Proc. Natl. Acad. Sci. U.S.A. 87:6151-6155(1990) [PubMed] [Europe PMC] [Abstract]
  12. "New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus."Genes Immun. 1:501-503(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation."J. Biol. Chem. 267:21172-21178(1992) [PubMed] [Europe PMC] [Abstract]
  14. "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor."Cell 78:681-692(1994) [PubMed] [Europe PMC] [Abstract]
  15. "Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis."Mol. Cell. Biol. 22:7512-7523(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of protein O-glycosylation site and corresponding glycans using liquid chromatography-tandem mass spectrometry via mapping accurate mass and retention time shift."J. Chromatogr. A 1371:136-145(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Structural basis for self-association and receptor recognition of human TRAF2."Nature 398:533-538(1999) [PubMed] [Europe PMC] [Abstract]
  18. "Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: molecular and functional analysis."Arthritis Rheum. 44:2819-2827(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism."J. Clin. Endocrinol. Metab. 87:3977-3983(2002) [PubMed] [Europe PMC] [Abstract]