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Colony Stimulating Factor Receptor, Macrophage (MCSFR)

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CD115; MCFSR; M-CSFR; CSF1R; CSF1-R; C-FMS; CSFR; FIM2; FMS; Colony Stimulating Factor 1 Receptor; Formerly McDonough Feline Sarcoma Viral(v-Fms)oncogene Homolog

Colony Stimulating Factor Receptor, Macrophage (MCSFR)
CCC B484
HGNC 2433
MGI 1339758
PubMed 6460630
RGD 2425
UniProt P07333
Wiki MCFSR

Colony stimulating factor 1 receptor is a cell-surface protein encoded, in humans, by the CSF1R gene. It is a receptor for a cytokine called colony stimulating factor 1.The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. The first intron of the CSFR1 gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene, oriented in the opposite direction to the CSFR1 gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB484Hu01 Recombinant Colony Stimulating Factor Receptor, Macrophage (MCSFR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB484Hu02 Recombinant Colony Stimulating Factor Receptor, Macrophage (MCSFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB484Hu01 Polyclonal Antibody to Colony Stimulating Factor Receptor, Macrophage (MCSFR) WB; IHC; ICC; IP.
LAB484Hu71 Biotin-Linked Polyclonal Antibody to Colony Stimulating Factor Receptor, Macrophage (MCSFR) WB; IHC; ICC.
MAB484Hu21 Monoclonal Antibody to Colony Stimulating Factor Receptor, Macrophage (MCSFR) WB; IHC; ICC; IP.
MAB484Hu22 Monoclonal Antibody to Colony Stimulating Factor Receptor, Macrophage (MCSFR) WB; IHC; ICC; IP.
MAB484Hu23 Monoclonal Antibody to Colony Stimulating Factor Receptor, Macrophage (MCSFR) WB; IHC; ICC; IP.
Assay Kits SEB484Hu ELISA Kit for Colony Stimulating Factor Receptor, Macrophage (MCSFR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB484Mu01 Recombinant Colony Stimulating Factor Receptor, Macrophage (MCSFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB484Mu01 Polyclonal Antibody to Colony Stimulating Factor Receptor, Macrophage (MCSFR) WB; IHC; ICC; IP.
LAB484Mu71 Biotin-Linked Polyclonal Antibody to Colony Stimulating Factor Receptor, Macrophage (MCSFR) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Colony Stimulating Factor Receptor, Macrophage (MCSFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Colony Stimulating Factor Receptor, Macrophage (MCSFR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB484Ra01 Recombinant Colony Stimulating Factor Receptor, Macrophage (MCSFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB484Ra01 Polyclonal Antibody to Colony Stimulating Factor Receptor, Macrophage (MCSFR) WB; IHC; ICC; IP.
LAB484Ra71 Biotin-Linked Polyclonal Antibody to Colony Stimulating Factor Receptor, Macrophage (MCSFR) WB; IHC; ICC.
Assay Kits SEB484Ra ELISA Kit for Colony Stimulating Factor Receptor, Macrophage (MCSFR) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Nucleotide sequence and structural organization of the human FMS proto-oncogene."Oncogene Res. 4:9-17(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus."Nature 320:277-280(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes."Genomics 39:216-226(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."Arthritis Res. Ther. 10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes."Mol. Cell. Biol. 9:1336-1341(1989) [PubMed] [Europe PMC] [Abstract]
  8. "The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences."J. Virol. 59:224-233(1986) [PubMed] [Europe PMC] [Abstract]
  9. "Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome."Cell 42:421-428(1985) [PubMed] [Europe PMC] [Abstract]
  10. "'Replacement' of COOH-terminal truncation of v-fms with c-fms sequences markedly reduces transformation potential."Proc. Natl. Acad. Sci. U.S.A. 83:7800-7804(1986) [PubMed] [Europe PMC] [Abstract]
  11. "Expression of human colony-stimulating factor-1 (CSF-1) receptor in murine pluripotent hematopoietic NFS-60 cells induces long-term proliferation in response to CSF-1 without loss of erythroid differentiation potential."Blood 81:2511-2520(1993) [PubMed] [Europe PMC] [Abstract]
  12. "Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor."EMBO J. 12:943-950(1993) [PubMed] [Europe PMC] [Abstract]
  13. "Transcriptional regulation of the c-fms (CSF-1R) proto-oncogene in human breast carcinoma cells by glucocorticoids."Oncogene 10:529-542(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Cell specific transformation by c-fms activating loop mutations is attributable to constitutive receptor degradation."Oncogene 18:3076-3084(1999) [PubMed] [Europe PMC] [Abstract]
  15. "The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity."J. Biol. Chem. 278:38628-38636(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture."J. Cell Biol. 165:263-273(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors."Mol. Cancer Ther. 5:1007-1013(2006) [PubMed] [Europe PMC] [Abstract]
  19. "A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model."Mol. Cancer Ther. 5:2634-2643(2006) [PubMed] [Europe PMC] [Abstract]
  20. "FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance."Oncogene 25:147-151(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome."Science 320:807-811(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals."Int. J. Cancer 124:215-222(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor."Cancer Res. 69:9498-9506(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Colony stimulating factor-1 receptor as a target for small molecule inhibitors."Bioorg. Med. Chem. 18:1789-1797(2010) [PubMed] [Europe PMC] [Abstract]
  26. "IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation."Cell Death Differ. 17:1917-1927(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood."Cytokine 52:215-220(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells."J. Leukoc. Biol. 88:495-505(2010) [PubMed] [Europe PMC] [Abstract]
  29. "CSF-1 regulation of the wandering macrophage: complexity in action."Trends Cell Biol. 14:628-638(2004) [PubMed] [Europe PMC] [Abstract]
  30. "Colony-stimulating factor-1 in immunity and inflammation."Curr. Opin. Immunol. 18:39-48(2006) [PubMed] [Europe PMC] [Abstract]
  31. "Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies."Int. Immunopharmacol. 8:1354-1376(2008) [PubMed] [Europe PMC] [Abstract]
  32. "Blood monocytes: development, heterogeneity, and relationship with dendritic cells."Annu. Rev. Immunol. 27:669-692(2009) [PubMed] [Europe PMC] [Abstract]
  33. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  34. "Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors."J. Biol. Chem. 282:4094-4101(2007) [PubMed] [Europe PMC] [Abstract]
  35. "The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain."J. Mol. Biol. 367:839-847(2007) [PubMed] [Europe PMC] [Abstract]
  36. "Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors."Bioorg. Med. Chem. Lett. 18:2355-2361(2008) [PubMed] [Europe PMC] [Abstract]
  37. "Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors."J. Med. Chem. 52:1081-1099(2009) [PubMed] [Europe PMC] [Abstract]
  38. "Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode."Bioorg. Med. Chem. Lett. 20:1543-1547(2010) [PubMed] [Europe PMC] [Abstract]
  39. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  40. "Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids." Nat. Genet. 44:200-205(2012) [PubMed] [Europe PMC] [Abstract]
  41. "Hereditary diffuse leukoencephalopathy with axonal spheroids: three patients with stroke-like presentation carrying new mutations in the CSF1R gene."J. Neurol. 261:768-772(2014) [PubMed] [Europe PMC] [Abstract]