-91477.jpg)
Matrix gla protein (MGP) is a protein found in numerous body tissues that requires vitamin K for its optimum function. It is present in bone (together with the related vitamin K-dependent protein osteocalcin), as well as in heart, kidney and lung. In bone, its production is increased by vitamin D.
MGP and osteocalcin are both calcium-binding proteins that may participate in the organisation of bone tissue. Both have glutamate residues that are post-translationally carboxylated by the enzyme gamma-glutamyl carboxylase in a reaction that requires Vitamin K hydroquinone. This process also occurs with a number of proteins involved in coagulation: prothrombin, factor VII, factor IX and factor X, protein C, protein S and protein Z.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB477Hu01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB477Hu01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| MAB477Hu22 | Monoclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB477Hu | ELISA Kit for Matrix Gla Protein (MGP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB477Mu01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB477Mu02 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB477Mu01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| LAB477Mu71 | Biotin-Linked Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC. | |
| PAB477Mu02 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB477Mu | ELISA Kit for Matrix Gla Protein (MGP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB477Ra01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB477Ra02 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB477Ra01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| LAB477Ra71 | Biotin-Linked Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC. | |
| LAB477Ra81 | FITC-Linked Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IF. | |
| PAB477Ra02 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB477Ra | ELISA Kit for Matrix Gla Protein (MGP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB477Rb01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB477Rb51 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Matrix Gla Protein (MGP) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Matrix Gla Protein (MGP) | ELISA Kit Customized Service Offer |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB477Po01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB477Po01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Matrix Gla Protein (MGP) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Matrix Gla Protein (MGP) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB477Bo01 | Recombinant Matrix Gla Protein (MGP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB477Bo01 | Polyclonal Antibody to Matrix Gla Protein (MGP) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Matrix Gla Protein (MGP) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Matrix Gla Protein (MGP) | ELISA Kit Customized Service Offer |
- "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene."J. Biol. Chem. 265:15040-15048(1990) [PubMed] [Europe PMC] [Abstract]
- "The cDNA and derived amino acid sequences for human and bovine matrix Gla protein."Nucleic Acids Res. 16:5213-5213(1988) [PubMed] [Europe PMC] [Abstract]
- "Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization."Oncogene 5:1391-1395(1990) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human."Protein Sci. 3:822-830(1994) [PubMed] [Europe PMC] [Abstract]
- "Carboxyl-terminal proteolytic processing of matrix Gla protein."J. Biol. Chem. 266:21145-21149(1991) [PubMed] [Europe PMC] [Abstract]
- "Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome."Nat. Genet. 21:142-144(1999) [PubMed] [Europe PMC] [Abstract]