≡

Colony Stimulating Factor Receptor, Granulocyte (GCSFR)

[Edit]

CD114; G-CSFR; CSF3R; CSF3-R; GCSF-R

Colony Stimulating Factor Receptor, Granulocyte (GCSFR)
CCC B476
HGNC 2439
MGI 1339755
PubMed 23136256
RGD 1309114
UniProt Q99062
Wiki GCSFR

The granulocyte colony-stimulating factor receptor (G-CSF-R) is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction.

Th G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. Mutations in the intracellular part of this receptor are associated with certain types of leukemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB476Hu01 Recombinant Colony Stimulating Factor Receptor, Granulocyte (GCSFR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB476Hu02 Recombinant Colony Stimulating Factor Receptor, Granulocyte (GCSFR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB476Hu03 Recombinant Colony Stimulating Factor Receptor, Granulocyte (GCSFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB476Hu01 Polyclonal Antibody to Colony Stimulating Factor Receptor, Granulocyte (GCSFR) WB; IHC; ICC/IF
PAB476Hu02 Polyclonal Antibody to Colony Stimulating Factor Receptor, Granulocyte (GCSFR) WB; ICC; IHC-P; IHC-F; ELISA.
LAB476Hu71 Biotin-Linked Polyclonal Antibody to Colony Stimulating Factor Receptor, Granulocyte (GCSFR) WB; IHC; ICC.
PAB476Hu03 Polyclonal Antibody to Colony Stimulating Factor Receptor, Granulocyte (GCSFR) WB; IHC; ICC; IP.
Assay Kits SEB476Hu ELISA Kit for Colony Stimulating Factor Receptor, Granulocyte (GCSFR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB476Mu01 Recombinant Colony Stimulating Factor Receptor, Granulocyte (GCSFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB476Mu01 Polyclonal Antibody to Colony Stimulating Factor Receptor, Granulocyte (GCSFR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Colony Stimulating Factor Receptor, Granulocyte (GCSFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Colony Stimulating Factor Receptor, Granulocyte (GCSFR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB476Ra01 Recombinant Colony Stimulating Factor Receptor, Granulocyte (GCSFR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB476Ra01 Polyclonal Antibody to Colony Stimulating Factor Receptor, Granulocyte (GCSFR) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Colony Stimulating Factor Receptor, Granulocyte (GCSFR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Colony Stimulating Factor Receptor, Granulocyte (GCSFR) ELISA Kit Customized Service Offer
  1. "Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains."J. Exp. Med. 172:1559-1570(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Three different mRNAs encoding human granulocyte colony-stimulating factor receptor."Proc. Natl. Acad. Sci. U.S.A. 87:8702-8706(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor."J. Immunol. 148:259-266(1992) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region."Arch. Biochem. Biophys. 324:344-356(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Functional domains of the granulocyte colony-stimulating factor receptor."EMBO J. 10:2855-2865(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia."Proc. Natl. Acad. Sci. U.S.A. 91:4480-4484(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders."Front. Biosci. 12:800-815(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Clinical implications of ELA2-, HAX1-, and G-CSF-receptor (CSF3R) mutations in severe congenital neutropenia."Br. J. Haematol. 144:459-467(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand."Nat. Struct. Biol. 4:498-504(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of a ligand-binding site on the granulocyte colony-stimulating factor receptor by molecular modeling and mutagenesis."J. Biol. Chem. 272:29735-29741(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex."Proc. Natl. Acad. Sci. U.S.A. 103:3135-3140(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment."J. Exp. Med. 190:497-507(1999) [PubMed] [Europe PMC] [Abstract]
  14. "An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia."J. Exp. Med. 206:1701-1707(2009) [PubMed] [Europe PMC] [Abstract]