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Chitinase-3-like Protein 1 (CHI3L1)

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GP39; CHI3-L1; YKL40; Chondrex; Chitinase 3-Like 1; Chondrocyte Protein YKL40; 39 kDa synovial protein

Chitinase-3-like Protein 1 (CHI3L1)
CCC B463
HGNC 1932
MGI 1340899
PubMed 1385114
RGD 620874
UniProt P36222
Wiki GP39

Cartilage glycoprotein-39 is one of the major secreted proteins of ex vivo cultured human articular chondrocytes, synovial cells, and macrophages and also expressed by mature neutrophils (from myelocyte-metamyelocyte stage). High levels of YKL-40 are found in synovial fluid from patients with active rheumatoid arthritis (RA) and in the hippocampus of schizophrenic patients. YKL-40 belongs to the 18-glycosyl hydrolase (mammalian chitinase) family, and is one of the putative autoantigens in rheumatoid arthritis (RA). High levels of YKL-40 are found in synovial fluid from patients with active RA. The name 'YKL' stands for its N-terminal tripeptide sequence, and unlike the other member YKL39 which is unglycosylated, YKL40 is glycosylated.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB463Hu01 Recombinant Chitinase-3-like Protein 1 (CHI3L1) Positive Control; Immunogen; SDS-PAGE; WB.
APB463Hu01 Active Chitinase-3-like Protein 1 (CHI3L1) Cell culture; Activity Assays.
Antibodies PAB463Hu01 Polyclonal Antibody to Chitinase-3-like Protein 1 (CHI3L1) WB; IHC; ICC; IP.
MAB463Hu22 Monoclonal Antibody to Chitinase-3-like Protein 1 (CHI3L1) WB; IHC; ICC; IP.
LAB463Hu82 FITC-Linked Monoclonal Antibody to Chitinase-3-like Protein 1 (CHI3L1) WB; IHC; ICC; IF.
LAB463Hu81 FITC-Linked Polyclonal Antibody to Chitinase-3-like Protein 1 (CHI3L1) WB; IHC; ICC; IF.
MAB463Hu23 Monoclonal Antibody to Chitinase-3-like Protein 1 (CHI3L1) WB; IHC; ICC; IP.
MAB463Hu21 Monoclonal Antibody to Chitinase-3-like Protein 1 (CHI3L1) WB; IHC; ICC; IP.
Assay Kits SEB463Hu ELISA Kit for Chitinase-3-like Protein 1 (CHI3L1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB463Mu01 Recombinant Chitinase-3-like Protein 1 (CHI3L1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB463Mu01 Polyclonal Antibody to Chitinase-3-like Protein 1 (CHI3L1) WB; IHC; ICC; IP.
Assay Kits SEB463Mu ELISA Kit for Chitinase-3-like Protein 1 (CHI3L1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB463Ra01 Recombinant Chitinase-3-like Protein 1 (CHI3L1) Positive Control; Immunogen; SDS-PAGE; WB.
APB463Ra01 Active Chitinase-3-like Protein 1 (CHI3L1) Cell culture; Activity Assays.
Antibodies PAB463Ra01 Polyclonal Antibody to Chitinase-3-like Protein 1 (CHI3L1) WB; IHC; ICC; IP.
MAB463Ra21 Monoclonal Antibody to Chitinase-3-like Protein 1 (CHI3L1) WB; IHC; ICC; IP.
Assay Kits SEB463Ra ELISA Kit for Chitinase-3-like Protein 1 (CHI3L1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family."J. Biol. Chem. 268:25803-25810(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation."Genomics 43:221-225(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period."Biochem. J. 269:265-268(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages."Eur. J. Biochem. 251:504-509(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells."Gastroenterology 130:398-411(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis."J. Exp. Med. 206:1149-1166(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury."Am. J. Respir. Crit. Care Med. 182:918-928(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes."J. Biol. Chem. 278:30206-30212(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39."J. Biol. Chem. 278:37753-37760(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function."N. Engl. J. Med. 358:1682-1691(2008) [PubMed] [Europe PMC] [Abstract]