Lipopolysaccharide Binding Protein (LBP)

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LPS-Binding Protein

Lipopolysaccharide Binding Protein (LBP)

LPS-binding protein (LBP) is serum factor known to regulate the endotoxin-induced cellular immune response. Sepsis is a morbid condition induced by a toxin, the introduction or accumulation of which is most commonly caused by infection or trauma. Sepsis-inducing toxins have been found associated with pathogenic bacteria, viruses, plants and venoms.

Among the well described bacterial toxins are the endotoxins or lipopolysaccharides (LPS) of the gram-negative bacteria. Upon introduction of LPS into the blood it binds to lipopolysaccharide binding protein (LBP). LBP recognizes the lipid A region of LPS and forms high affinity complexes with both rough and smooth form LPS. During the acute phase, LBP is synthesized by hepatocytes, and reaches very high concentrations in serum.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB406Hu01 Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
APB406Hu01 Active Lipopolysaccharide Binding Protein (LBP) Cell culture; Activity Assays.
RPB406Hu02 Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB406Hu01 Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
MAB406Hu22 Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
LAB406Hu71 Biotin-Linked Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC.
MAB406Hu21 Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC
Assay Kits SEB406Hu ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB406Mu01 Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB406Mu02 Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
APB406Mu02 Active Lipopolysaccharide Binding Protein (LBP) Cell culture; Activity Assays.
APB406Mu01 Active Lipopolysaccharide Binding Protein (LBP) Cell culture; Activity Assays.
Antibodies PAB406Mu01 Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
PAB406Mu02 Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
Assay Kits SEB406Mu ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB406Ra01 Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB406Ra02 Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB406Ra01 Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
MAB406Ra21 Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
PAB406Ra02 Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
LAB406Ra41 PE-Linked Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IF.
Assay Kits SEB406Ra ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection.
HEB406Ra High Sensitive ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB406Rb01 Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB406Rb51 Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
PAB406Rb01 Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Lipopolysaccharide Binding Protein (LBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lipopolysaccharide Binding Protein (LBP) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB406Po01 Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB406Po02 Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB406Po03 Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
APB406Po02 Active Lipopolysaccharide Binding Protein (LBP) Cell culture; Activity Assays.
Antibodies PAB406Po01 Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
MAB406Po21 Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
Assay Kits SEB406Po ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB406Bo01 Recombinant Lipopolysaccharide Binding Protein (LBP) Positive Control; Immunogen; SDS-PAGE; WB.
APB406Bo01 Active Lipopolysaccharide Binding Protein (LBP) Cell culture; Activity Assays.
Antibodies PAB406Bo01 Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
MAB406Bo21 Monoclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC; IP.
LAB406Bo71 Biotin-Linked Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP) WB; IHC; ICC.
Assay Kits SEB406Bo ELISA Kit for Lipopolysaccharide Binding Protein (LBP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structure and function of lipopolysaccharide binding protein."Science 249:1429-1431(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation."J. Biol. Chem. 269:17411-17416(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved."Biochem. Biophys. Res. Commun. 236:427-430(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins."Genomics 46:416-425(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and sequencing of human lipopolysaccharide-binding protein gene."Sheng Wu Hua Xue Yu Sheng Wu Wu Li Jin Zhan 25:469-471(1998)
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Structural biology of the LPS recognition."Int. J. Med. Microbiol. 297:353-363(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity."Immunity 39:647-660(2013) [PubMed] [Europe PMC] [Abstract]