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Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 3 (LILRA3)

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CD85e; HM31; HM43; ILT6; LIR4; E3; CD85 antigen-like family member E; Immunoglobulin-like transcript 6; Leukocyte immunoglobulin-like receptor 4

Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 3 (LILRA3)
CCC B387
HGNC 6604
PubMed 20595277
UniProt Q8N6C8
Wiki LILRA3

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function . LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades .

Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB387Hu01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 3 (LILRA3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB387Hu01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 3 (LILRA3) WB; IHC; ICC; IP.
MAB387Hu22 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 3 (LILRA3) WB; IHC; ICC; IP.
Assay Kits SEB387Hu ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 3 (LILRA3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor."J. Immunol. 159:2342-2349(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways."Eur. J. Immunol. 27:660-665(1997) [PubMed] [Europe PMC] [Abstract]
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  6. "DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3."Immunogenetics 55:165-171(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Glycosylation in a mammalian expression system is critical for the production of functionally active leukocyte immunoglobulin-like receptor A3 protein."J. Biol. Chem. 288:32873-32885(2013) [PubMed] [Europe PMC] [Abstract]
  9. "LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence."PLoS ONE 6:E19245-E19245(2011) [PubMed] [Europe PMC] [Abstract]