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Gamma-Glutamyltransferase 1 (gGT1)

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CD224; G-GT1; GTG; Gamma-glutamyltranspeptidase 1; Glutathione hydrolase 1; Leukotriene-C4 hydrolase;

Gamma-Glutamyltransferase 1 (gGT1)
CCC B375
HGNC 4250
MGI 95706
PubMed 17316175
RGD 2683
UniProt P19440
Wiki GGT1

Gamma-Glutamyltransferase 1 (gGT1) belongs to the gamma-glutamyltransferase family. It is a heterodimer, consists of two polypeptide chains, a heavy chain and a light chain. The active site of gGT1 is located in the light chain. gGT1 is activated by autocatalytic cleavage, and cleaved by autocatalysis into a large and a small subunit, the autocatalytic cleavage is essential to the functional activation of gGT1. gGT1 is crucial for metabolism of glutathione, it can cleave the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4). gGT1 is used as a diagnostic marker for liver diseases. Besides, in diseases of the liver, pancreas and biliary system, gGT1 activity in serum is elevated. Slightly elevated levels of serum gGT1 has also been found to be associated with cardiovascular diseases. And gGT1 is expressed at high levels in many different tumors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB375Hu01 Recombinant Gamma-Glutamyltransferase 1 (gGT1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB375Hu02 Recombinant Gamma-Glutamyltransferase 1 (gGT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB375Hu01 Polyclonal Antibody to Gamma-Glutamyltransferase 1 (gGT1) WB; IHC; ICC; IP.
MAB375Hu22 Monoclonal Antibody to Gamma-Glutamyltransferase 1 (gGT1) WB,IHC
PAB375Hu02 Polyclonal Antibody to Gamma-Glutamyltransferase 1 (gGT1) WB; IHC; ICC; IP.
MAB375Hu21 Monoclonal Antibody to Gamma-Glutamyltransferase 1 (gGT1) WB
Assay Kits SEB375Hu ELISA Kit for Gamma-Glutamyltransferase 1 (gGT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB375Mu01 Recombinant Gamma-Glutamyltransferase 1 (gGT1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB375Mu02 Recombinant Gamma-Glutamyltransferase 1 (gGT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB375Mu01 Polyclonal Antibody to Gamma-Glutamyltransferase 1 (gGT1) WB; IHC; ICC; IP.
PAB375Mu02 Polyclonal Antibody to Gamma-Glutamyltransferase 1 (gGT1) WB; IHC; ICC; IP.
Assay Kits SEB375Mu ELISA Kit for Gamma-Glutamyltransferase 1 (gGT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gamma-Glutamyltransferase 1 (gGT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gamma-Glutamyltransferase 1 (gGT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gamma-Glutamyltransferase 1 (gGT1) Polyclonal Antibody Customized Service Offer
Assay Kits SEB375Ra ELISA Kit for Gamma-Glutamyltransferase 1 (gGT1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase."Proc. Natl. Acad. Sci. U.S.A. 85:8840-8844(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The primary structure of human gamma-glutamyl transpeptidase."Gene 73:1-9(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis."Toxicol. Appl. Pharmacol. 97:23-34(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Human gamma-glutamyl transpeptidase cDNA: comparison of hepatoma and kidney mRNA in the human and rat."Gene 76:1-9(1989) [PubMed] [Europe PMC] [Abstract]
  5. "An alternatively processed mRNA specific for gamma-glutamyl transpeptidase in human tissues."J. Biol. Chem. 265:3256-3262(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Gamma-glutamyltransferase: nucleotide sequence of the human pancreatic cDNA. Evidence for a ubiquitous gamma-glutamyltransferase polypeptide in human tissues."Biochem. Pharmacol. 43:2527-2533(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Human lung expresses unique gamma-glutamyl transpeptidase transcripts."Proc. Natl. Acad. Sci. U.S.A. 90:7461-7465(1993) [PubMed] [Europe PMC] [Abstract]
  8. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Renal gamma-glutamyl transpeptidases: structural and immunological studies."Arch. Biochem. Biophys. 262:397-408(1988) [PubMed] [Europe PMC] [Abstract]
  12. "Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species."Comp. Biochem. Physiol. 122B:367-380(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit."J. Biol. Chem. 252:6042-6045(1977) [PubMed] [Europe PMC] [Abstract]
  14. "In vitro translation and processing of human hepatoma cell (Hep G2) gamma-glutamyl transpeptidase."Biochem. Biophys. Res. Commun. 154:1167-1173(1988) [PubMed] [Europe PMC] [Abstract]
  15. "Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase. Identification by site-directed mutagenesis."J. Biol. Chem. 268:3980-3985(1993) [PubMed] [Europe PMC] [Abstract]
  16. "Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit."J. Biol. Chem. 270:12471-12475(1995) [PubMed] [Europe PMC] [Abstract]
  17. "Involvement of Ser-451 and Ser-452 in the catalysis of human gamma-glutamyl transpeptidase."J. Biol. Chem. 270:22223-22228(1995) [PubMed] [Europe PMC] [Abstract]
  18. "Effects of substitutions of the conserved histidine residues in human gamma-glutamyl transpeptidase."J. Biochem. 119:1166-1170(1996) [PubMed] [Europe PMC] [Abstract]
  19. "A proteomic analysis of human bile."Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human gamma-glutamyltranspeptidase."Biochemistry 46:12253-12262(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Analysis of site-specific glycosylation of renal and hepatic gamma-glutamyl transpeptidase from normal human tissue."J. Biol. Chem. 285:29511-29524(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Human GGT2 does not autocleave into a functional enzyme: a cautionary tale for interpretation of microarray data on redox signaling."Antioxid. Redox Signal. 19:1877-1888(2013) [PubMed] [Europe PMC] [Abstract]
  25. "Novel insights into eukaryotic gamma-glutamyl transpeptidase 1 from the crystal structure of the glutamate-bound human enzyme."J. Biol. Chem. 288:31902-31913(2013) [PubMed] [Europe PMC] [Abstract]