≡

Bcl2 Associated X Protein (Bax)

[Edit]

BCL2L4; Bax Zeta; Apoptosis regulator BAX; Bcl-2-like protein 4

Bcl2 Associated X Protein (Bax)
CCC B343
HGNC 959
MGI 99702
PubMed 23258611
RGD 2192
UniProt Q07812
Wiki BAX

Bax (Bcl-2 associated x protein) is an apoptosis regulating protein of the Bcl-2 family. The ratio of Bax to Bcl-2 determines survival or death following an apoptotic stimulus. Bax is implicated in many cancers, uterine leiomyomas, and brain dysmorphology. Bax is a 21 kDa protein that accelerates apoptosis by binding to, and antagonizing the death repressor activity of Bcl-2 in vivo.

Bax normally resides in the cytoplasm, but following an apoptotic stimuli, Bax undergoes a conformational change and translocates to mitochondrial membranes, where it inserts and mediates the release of cytochrome c from the intermembrane space into the cytosol, in this manner activating caspase-3 and perpetuating the apoptotic cascade.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB343Hu01 Recombinant Bcl2 Associated X Protein (Bax) Positive Control; Immunogen; SDS-PAGE; WB.
CPB343Hu21 OVA Conjugated Bcl2 Associated X Protein (Bax) Immunogen; SDS-PAGE; WB.
RPB343Hu02 Recombinant Bcl2 Associated X Protein (Bax) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB343Hu01 Polyclonal Antibody to Bcl2 Associated X Protein (Bax) WB; IHC; ICC; IP.
MAB343Hu22 Monoclonal Antibody to Bcl2 Associated X Protein (Bax) WB; IHC; ICC; IP.
Assay Kits SEB343Hu ELISA Kit for Bcl2 Associated X Protein (Bax) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB343Mu01 Recombinant Bcl2 Associated X Protein (Bax) Positive Control; Immunogen; SDS-PAGE; WB.
RPB343Mu02 Recombinant Bcl2 Associated X Protein (Bax) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB343Mu01 Polyclonal Antibody to Bcl2 Associated X Protein (Bax) WB; IHC; ICC; IP.
PAB343Mu02 Polyclonal Antibody to Bcl2 Associated X Protein (Bax) WB; IHC; ICC; IP.
Assay Kits SEB343Mu ELISA Kit for Bcl2 Associated X Protein (Bax) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB343Ra01 Recombinant Bcl2 Associated X Protein (Bax) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB343Ra01 Polyclonal Antibody to Bcl2 Associated X Protein (Bax) WB; IHC; ICC; IP.
MAB343Ra21 Monoclonal Antibody to Bcl2 Associated X Protein (Bax) WB; IHC; ICC; IP.
Assay Kits SEB343Ra ELISA Kit for Bcl2 Associated X Protein (Bax) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB343Po01 Recombinant Bcl2 Associated X Protein (Bax) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB343Po01 Polyclonal Antibody to Bcl2 Associated X Protein (Bax) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Bcl2 Associated X Protein (Bax) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bcl2 Associated X Protein (Bax) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB343Bo01 Recombinant Bcl2 Associated X Protein (Bax) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB343Bo01 Polyclonal Antibody to Bcl2 Associated X Protein (Bax) WB; IHC; ICC; IP.
MAB343Bo21 Monoclonal Antibody to Bcl2 Associated X Protein (Bax) WB; IHC; ICC; IP.
Assay Kits SEB343Bo ELISA Kit for Bcl2 Associated X Protein (Bax) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death."Cell 74:609-619(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta."Genomics 26:592-594(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and characterization of baxepsilon, a novel bax variant missing the BH2 and the transmembrane domains."Biochem. Biophys. Res. Commun. 254:779-785(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of Bax-sigma, a cell death-inducing isoform of Bax."Biochem. Biophys. Res. Commun. 270:868-879(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients."Hum. Mol. Genet. 11:675-687(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Bax mutations in cell lines derived from hematological malignancies."Leukemia 9:1828-1832(1995) [PubMed] [Europe PMC] [Abstract]
  9. "A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions."EMBO J. 14:5589-5596(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Conformation of the Bax C-terminus regulates subcellular location and cell death."EMBO J. 18:2330-2341(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax."J. Biol. Chem. 276:20559-20565(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Humanin peptide suppresses apoptosis by interfering with Bax activation."Nature 423:456-461(2003) [PubMed] [Europe PMC] [Abstract]
  13. "JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins."EMBO J. 23:1889-1899(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation."J. Biol. Chem. 279:21233-21238(2004) [PubMed] [Europe PMC] [Abstract]
  15. "An anti-apoptotic viral protein that recruits Bax to mitochondria."J. Biol. Chem. 279:22605-22614(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Clusterin inhibits apoptosis by interacting with activated Bax."Nat. Cell Biol. 7:909-915(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Sequence analysis shows that Lifeguard belongs to a new evolutionarily conserved cytoprotective family."Int. J. Mol. Med. 18:729-734(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation."EMBO J. 29:1458-1471(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Human Bop is a novel BH3-only member of the Bcl-2 protein family."Protein Cell 3:790-801(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Structure of Bax: coregulation of dimer formation and intracellular localization."Cell 103:645-654(2000) [PubMed] [Europe PMC] [Abstract]
  23. "Elucidation of some Bax conformational changes through crystallization of an antibody-peptide complex."Cell Death Differ. 14:447-452(2007) [PubMed] [Europe PMC] [Abstract]
  24. "BAX activation is initiated at a novel interaction site."Nature 455:1076-1081(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis."J. Biol. Chem. 286:7123-7131(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Hematopoietic malignancies demonstrate loss-of-function mutations of BAX."Blood 91:2991-2997(1998) [PubMed] [Europe PMC] [Abstract]