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Ornithine Decarboxylase (ODC)

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ODC1

Ornithine Decarboxylase (ODC)
CCC B332
HGNC 8109
MGI 97402
PubMed 15894264
RGD 3227
UniProt P11926
Wiki ODC

The enzyme ornithine decarboxylase (ODC) participates in the urea cycle, and in the metabolism of glutathione and amino groups. In humans, this protein has 461 amino acids and forms a homodimer. ODC gene expression is induced by a large number of biological stimuli including seizure activity in the brain.

Inactivation of ODC by difluoromethylornithine (eflornithine) is used to treat cancer, sickness and facial hair growth in postmenopausal females. ODC is also an enzyme indispensable to parasites like trypanosoma, giardia and plasmodium. A fact exploited by the drug eflornithine. ODC is the most well-characterized cellular protein subject to ubiquitin-independent proteasomal degradation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB332Hu01 Recombinant Ornithine Decarboxylase (ODC) Positive Control; Immunogen; SDS-PAGE; WB.
RPB332Hu02 Recombinant Ornithine Decarboxylase (ODC) Positive Control; Immunogen; SDS-PAGE; WB.
APB332Hu01 Active Ornithine Decarboxylase (ODC) Cell culture; Activity Assays.
APB332Hu02 Active Ornithine Decarboxylase (ODC) Cell culture; Activity Assays.
RPB332Hu03 Recombinant Ornithine Decarboxylase (ODC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB332Hu01 Polyclonal Antibody to Ornithine Decarboxylase (ODC) WB; IHC; ICC; IP.
MAB332Hu22 Monoclonal Antibody to Ornithine Decarboxylase (ODC) WB; IHC; ICC; IP.
PAB332Hu02 Polyclonal Antibody to Ornithine Decarboxylase (ODC) WB; IHC; ICC; IP.
LAB332Hu71 Biotin-Linked Polyclonal Antibody to Ornithine Decarboxylase (ODC) WB; IHC; ICC.
Assay Kits SEB332Hu ELISA Kit for Ornithine Decarboxylase (ODC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB332Mu01 Recombinant Ornithine Decarboxylase (ODC) Positive Control; Immunogen; SDS-PAGE; WB.
RPB332Mu02 Recombinant Ornithine Decarboxylase (ODC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB332Mu01 Polyclonal Antibody to Ornithine Decarboxylase (ODC) WB; IHC; ICC; IP.
PAB332Mu02 Polyclonal Antibody to Ornithine Decarboxylase (ODC) WB; IHC; ICC; IP.
Assay Kits SEB332Mu ELISA Kit for Ornithine Decarboxylase (ODC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB332Ra01 Recombinant Ornithine Decarboxylase (ODC) Positive Control; Immunogen; SDS-PAGE; WB.
APB332Ra01 Active Ornithine Decarboxylase (ODC) Cell culture; Activity Assays.
Antibodies PAB332Ra01 Polyclonal Antibody to Ornithine Decarboxylase (ODC) WB; IHC; ICC; IP.
MAB332Ra21 Monoclonal Antibody to Ornithine Decarboxylase (ODC) WB; IHC; ICC; IP.
Assay Kits SEB332Ra ELISA Kit for Ornithine Decarboxylase (ODC) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Complete amino acid sequence of human ornithine decarboxylase deduced from complementary DNA."DNA 6:179-187(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization and sequence analysis of the human ornithine decarboxylase gene."DNA 8:623-634(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Nucleotide sequence of the human ornithine decarboxylase gene."Nucleic Acids Res. 17:8855-8856(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene."Gene 93:257-263(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation and expression of a human ornithine decarboxylase gene."J. Biol. Chem. 265:4884-4892(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells."Nucleic Acids Res. 20:2581-2590(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element."Cell Growth Differ. 6:1097-1102(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Expression of human chromosome 2 ornithine decarboxylase gene in ornithine decarboxylase-deficient Chinese hamster ovary cells."Cancer Res. 50:2239-2244(1990) [PubMed] [Europe PMC] [Abstract]
  12. "Cell-cycle-dependent expression of human ornithine decarboxylase."J. Cell. Physiol. 132:545-551(1987) [PubMed] [Europe PMC] [Abstract]
  13. "Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation."Biochem. Biophys. Res. Commun. 262:355-358(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme."J. Biol. Chem. 276:34458-34464(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."Cell. Microbiol. 8:565-580(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase."Biochem. J. 409:187-192(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding."J. Mol. Biol. 295:7-16(2000) [PubMed] [Europe PMC] [Abstract]