Complement Component 8b (C8b)

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Complement component 8 subunit beta

Complement Component 8b (C8b)

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.Patients with deficiency of C8 suffer from recurrent neisserial infections, predominantly with meningococcus infection of rare serotypes. Most such patients are discovered among those having their first episode of meningitis at ages older than 10 years. C8 deficiency of the alpha and gamma subunits was found in 4 black families and no Caucasian families by Ross and Densen (1984), whereas C8B deficiency was reported in 12 Caucasian kindreds and no black kindreds. Wulffraat et al. (1994) described a family in which a 13-year-old boy was found to be homozygous for C8B deficiency and to have juvenile chronic arthritis of 6 months' duration.Antinuclear antibodies, anti-double-stranded DNA antibodies, and rheumatoid factor were not detected.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB306Hu01 Recombinant Complement Component 8b (C8b) Positive Control; Immunogen; SDS-PAGE; WB.
APB306Hu01 Active Complement Component 8b (C8b) Cell culture; Activity Assays.
Antibodies PAB306Hu01 Polyclonal Antibody to Complement Component 8b (C8b) WB; IHC; ICC; IP.
MAB306Hu21 Monoclonal Antibody to Complement Component 8b (C8b) WB; IHC; ICC; IP.
Assay Kits SEB306Hu ELISA Kit for Complement Component 8b (C8b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB306Mu01 Recombinant Complement Component 8b (C8b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB306Mu01 Polyclonal Antibody to Complement Component 8b (C8b) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Complement Component 8b (C8b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 8b (C8b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB306Ra01 Recombinant Complement Component 8b (C8b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB306Ra01 Polyclonal Antibody to Complement Component 8b (C8b) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Complement Component 8b (C8b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 8b (C8b) ELISA Kit Customized Service Offer
  1. "Complementary DNA and derived amino acid sequence of the beta subunit of human complement protein C8: identification of a close structural and ancestral relationship to the alpha subunit and C9."Biochemistry 26:3565-3570(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complementary DNA cloning of complement C8 beta and its sequence homology to C9."Biochemistry 26:3551-3556(1987) [PubMed] [Europe PMC] [Abstract]
  6. "The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure."J. Biol. Chem. 255:11997-12005(1980) [PubMed] [Europe PMC] [Abstract]
  7. "The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues."J. Biol. Chem. 274:32786-32794(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement."J. Biol. Chem. 286:17585-17592(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Human complement component C8. Molecular basis of the beta-chain polymorphism."FEBS Lett. 340:211-215(1994) [PubMed] [Europe PMC] [Abstract]