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Lipase, Hormone Sensitive (LIPE)

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HSL; LHS; Hormone Sensitive Lipase

Lipase, Hormone Sensitive (LIPE)
CCC B276
HGNC 6621
MGI 96790
PubMed 12364542
RGD 3010
UniProt Q05469
Wiki LIPE
LIPE) is an intracellular neutral lipase that is capable of hydrolyzing a variety of esters. The enzyme has a long and a short form. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.
LIPE is activated when the body needs to mobilize energy stores, and so responds positively to catecholamines, ACTH, and negatively to insulin. Previously, glucagon was thought to activate LIPE, however the removal of insulin's inhibitory effects ("cutting the brakes") is the source of activation. The lipolytic effect of glucagon in adipose tissue is minimal in humans.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB276Hu01 Recombinant Lipase, Hormone Sensitive (LIPE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB276Hu01 Polyclonal Antibody to Lipase, Hormone Sensitive (LIPE) WB; IHC; ICC; IP.
MAB276Hu22 Monoclonal Antibody to Lipase, Hormone Sensitive (LIPE) WB; IHC; ICC; IP.
MAB276Hu21 Monoclonal Antibody to Lipase, Hormone Sensitive (LIPE) WB; IHC; ICC; IP.
Assay Kits SEB276Hu ELISA Kit for Lipase, Hormone Sensitive (LIPE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB276Mu01 Recombinant Lipase, Hormone Sensitive (LIPE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB276Mu01 Polyclonal Antibody to Lipase, Hormone Sensitive (LIPE) WB; IHC; ICC; IP.
Assay Kits SEB276Mu ELISA Kit for Lipase, Hormone Sensitive (LIPE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB276Ra01 Recombinant Lipase, Hormone Sensitive (LIPE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB276Ra01 Polyclonal Antibody to Lipase, Hormone Sensitive (LIPE) WB; IHC; ICC; IP.
MAB276Ra21 Monoclonal Antibody to Lipase, Hormone Sensitive (LIPE) WB; IHC; ICC; IP.
Assay Kits SEB276Ra ELISA Kit for Lipase, Hormone Sensitive (LIPE) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium."Proc. Natl. Acad. Sci. U.S.A. 90:4897-4901(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase."Genomics 35:441-447(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Association and insulin regulated translocation of hormone-sensitive lipase with PTRF."Biochem. Biophys. Res. Commun. 350:657-661(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes; segregation of specific proteins and functions."FEBS J. 273:3381-3392(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes."N. Engl. J. Med. 370:2307-2315(2014) [PubMed] [Europe PMC] [Abstract]
  8. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]