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Kininogen 1 (KNG1)

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BDK; KNG; HMWK; Alpha-2-Thiol Proteinase Inhibitor; Bradykinin; Kallidin; Fitzgerald factor; High molecular weight kininogen; Williams-Fitzgerald-Flaujeac factor; Ile-Ser-Bradykinin

Kininogen 1 (KNG1)
CCC B267
HGNC 6383
MGI 3027157
PubMed 23894665
RGD 2980
UniProt P01042
Wiki Kininogen_1
High molecular weight kininogen (HMWK) plays an important role in assembly of the plasma kallikrein -kinin system. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. Both HMWK and LMWK contain an identical heavy chain consisting of protein domains 1, 2, and 3. However, HMWK contains a 56-kD light chain that consists of domains 5 and 6H, whereas LMWK contains a unique 4-kD light chain that consists of domain 5L. In both proteins, the heavy and light chains are linked by domain 4, which contains the bradykinin (BK) nonapeptide. BK, which is released by plasma kallikrein, is a potent inflammatory mediator that causes vasodilation and enhanced capillary permeability, induces pain, and stimulates production of nitric oxide and prostacyclin from endothelial cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB267Hu01 Recombinant Kininogen 1 (KNG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB267Hu01 Polyclonal Antibody to Kininogen 1 (KNG1) WB; IHC; ICC; IP.
MAB267Hu22 Monoclonal Antibody to Kininogen 1 (KNG1) WB; IHC; ICC; IP.
Assay Kits SEB267Hu ELISA Kit for Kininogen 1 (KNG1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB267Mu01 Recombinant Kininogen 1 (KNG1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB267Mu02 Recombinant Kininogen 1 (KNG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB267Mu01 Polyclonal Antibody to Kininogen 1 (KNG1) WB; IHC; ICC; IP.
PAB267Mu02 Polyclonal Antibody to Kininogen 1 (KNG1) WB; IHC; ICC; IP.
Assay Kits SEB267Mu ELISA Kit for Kininogen 1 (KNG1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB267Ra01 Recombinant Kininogen 1 (KNG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB267Ra01 Polyclonal Antibody to Kininogen 1 (KNG1) WB; IHC; ICC; IP.
MAB267Ra21 Monoclonal Antibody to Kininogen 1 (KNG1) WB; IHC; ICC; IP.
Assay Kits SEB267Ra ELISA Kit for Kininogen 1 (KNG1) Enzyme-linked immunosorbent assay for Antigen Detection.
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