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BPI was initially identified in neutrophils, but is found in other tissues including the epithelial lining of mucus membranes. It is an endogenous antibiotic protein with potent killing activity against some bacteria (Gram-negative bacteria). It binds to compounds called lipopolysaccharides produced by Gram-negative bacteria. Lipolysaccharides are potent activators of the immune system, however BPI at certain concentrations can prevent this activation.
Because lipopolysaccharides are potent inflammatory agents, and the action of antibiotics can result in the release of these compounds, the binding capacity of BPI was explored as a possible means of reducing injury. Xoma Ltd. developed a recombinant 25kDa portion of the BPI molecule called rBPI21, NEUPREX or opebecan.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB234Hu01 | Recombinant Bactericidal/Permeability Increasing Protein (BPI) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB234Hu02 | Recombinant Bactericidal/Permeability Increasing Protein (BPI) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB234Hu01 | Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) | WB; IHC; ICC; IP. |
| MAB234Hu22 | Monoclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) | WB; IHC; ICC; IP. | |
| PAB234Hu02 | Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB234Hu | ELISA Kit for Bactericidal/Permeability Increasing Protein (BPI) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB234Mu01 | Recombinant Bactericidal/Permeability Increasing Protein (BPI) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB234Mu02 | Recombinant Bactericidal/Permeability Increasing Protein (BPI) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB234Mu01 | Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) | WB; IHC; ICC; IP. |
| PAB234Mu02 | Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB234Mu | ELISA Kit for Bactericidal/Permeability Increasing Protein (BPI) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB234Ra01 | Recombinant Bactericidal/Permeability Increasing Protein (BPI) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB234Ra01 | Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) | WB; IHC; ICC; IP. |
| LAB234Ra71 | Biotin-Linked Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Bactericidal/Permeability Increasing Protein (BPI) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Bactericidal/Permeability Increasing Protein (BPI) | ELISA Kit Customized Service Offer |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB234Rb01 | Recombinant Bactericidal/Permeability Increasing Protein (BPI) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB234Rb51 | Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Bactericidal/Permeability Increasing Protein (BPI) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Bactericidal/Permeability Increasing Protein (BPI) | ELISA Kit Customized Service Offer |
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