Synuclein Alpha (SNCa)
[Edit]SNC-A; aSYN; PD1; PARK1; PARK4; NACP; Non-A Beta Component Of Alzheimer's Disease Amyloid Precursor Protein; Non-A4 component of amyloid precursor
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Alpha-synuclein also known as SNCA is a protein .An alpha-synuclein fragment, known as the non-Abeta component (NAC) of Alzheimer's disease amyloid, originally found in an amyloid-enriched fraction, is shown to be a fragment of its precursor protein, NACP, by cloning of the full-length cDNA. Later, NACP turned out to be a human homologue of Torpedo synuclein. Therefore, NACP is also referred to as human alpha-synuclein.
Alpha-synuclein is specifically upregulated in a discrete population of presynaptic terminals of the brain during a period of acquisition-related synaptic rearrangement. It has been shown that alpha-synuclein significantly interacts with tubulin, and that alpha-synuclein may have an activity as potential microtubule-associated protein like tau.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB222Hu01 | Recombinant Synuclein Alpha (SNCa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB222Hu01 | Polyclonal Antibody to Synuclein Alpha (SNCa) | WB; IHC; ICC; IP. |
| MAB222Hu22 | Monoclonal Antibody to Synuclein Alpha (SNCa) | WB; IHC; ICC; IP. | |
| LAB222Hu71 | Biotin-Linked Polyclonal Antibody to Synuclein Alpha (SNCa) | WB; IHC; ICC. | |
| Assay Kits | SEB222Hu | ELISA Kit for Synuclein Alpha (SNCa) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| AEB222Hu | ELISA Kit for Anti-Synuclein Alpha Antibody (Anti-SNCa) | Enzyme-linked immunosorbent assay for Antibody Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB222Mu01 | Recombinant Synuclein Alpha (SNCa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB222Mu02 | Recombinant Synuclein Alpha (SNCa) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB222Mu01 | Polyclonal Antibody to Synuclein Alpha (SNCa) | WB; IHC; ICC; IP. |
| PAB222Mu02 | Polyclonal Antibody to Synuclein Alpha (SNCa) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB222Mu | ELISA Kit for Synuclein Alpha (SNCa) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB222Ra01 | Recombinant Synuclein Alpha (SNCa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB222Ra01 | Polyclonal Antibody to Synuclein Alpha (SNCa) | WB; IHC; ICC; IP. |
| MAB222Ra21 | Monoclonal Antibody to Synuclein Alpha (SNCa) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB222Ra | ELISA Kit for Synuclein Alpha (SNCa) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease."Proc. Natl. Acad. Sci. U.S.A. 90:11282-11286(1993) [PubMed] [Europe PMC] [Abstract]
- "The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease."Genomics 26:254-257(1995) [PubMed] [Europe PMC] [Abstract]
- "Tissue-dependent alternative splicing of mRNA for NACP, the precursor of non-A beta component of Alzheimer's disease amyloid."Biochem. Biophys. Res. Commun. 205:1366-1372(1994) [PubMed] [Europe PMC] [Abstract]
- "Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element."Genome Res. 11:78-86(2001) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]