Hyaluronidase (HAase)

Hyaluronidase intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. Hyaluronidases may play a role in cancer metastasis. It has been hypothesized that by helping degrade the extracellular matrix (ECM) surrounding the tumor, hyaluronidases help cancer cells escape from primary tumor masses. Hyaluronidases are also thought play a role in the process of angiogenesis, although most hyaluronidase preparations are contaminated with large amounts of angiogeneic growth factors. As previously mentioned, there are six hyaluronidase genes in the human genome, four of which can express active hyaluronidases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB217Hu01 Recombinant Hyaluronidase (HAase) Positive Control; Immunogen; SDS-PAGE; WB.
RPB217Hu02 Recombinant Hyaluronidase (HAase) Positive Control; Immunogen; SDS-PAGE; WB.
APB217Hu61 Active Hyaluronidase (HAase) Cell culture; Activity Assays.
Antibodies PAB217Hu01 Polyclonal Antibody to Hyaluronidase (HAase) WB; IHC; ICC; IP.
Assay Kits SEB217Hu ELISA Kit for Hyaluronidase (HAase) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB217Hu CLIA Kit for Hyaluronidase (HAase) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Complete Antigen of Hyaluronidase (HAase) Antigenic Transformation Customized Service Offer
Antibodies PAB217Mu01 Polyclonal Antibody to Hyaluronidase (HAase) WB; IHC; ICC; IP.
Assay Kits SEB217Mu ELISA Kit for Hyaluronidase (HAase) Enzyme-linked immunosorbent assay for Antigen Detection.