Interleukin 19 (IL19)

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MDA1; ZMDA1, IL-10C, NG.1; Melanoma Differentiation Associated Protein-Like Protein

Interleukin 19 (IL19)

Interleukin-19 is a cytokine that belongs to the IL-10 family of cytokines along with several other interleukins including IL-10, IL-20, IL-22, IL-24, IL-26, and several virus-encoded cytokines. It signals through the same cell surface receptor (IL-20R) that is used by IL-20 and IL-24. The IL-19 gene is expressed in resting monocytes and B cells. It is up-regulated in monocytes following stimulation with GM-CSF or lipopolysaccharide.

The predicted 177-amino acid protein contains a signal peptide, 2 potential N-linked glycosylation sites, and 4 conserved cysteine residues necessary for correct folding of the IL10 monomer. IL19 shares 82% identity with IL10 in the hydrophobic core, but only 53% similarity in the putative IL10 receptor-alpha (IL10RA)-interacting residues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB190Hu01 Recombinant Interleukin 19 (IL19) Positive Control; Immunogen; SDS-PAGE; WB.
APB190Hu01 Active Interleukin 19 (IL19) Cell culture; Activity Assays.
EPB190Hu61 Eukaryotic Interleukin 19 (IL19) Positive Control; Immunogen; SDS-PAGE; WB.
APB190Hu61 Active Interleukin 19 (IL19) Cell culture; Activity Assays.
Antibodies PAB190Hu01 Polyclonal Antibody to Interleukin 19 (IL19) WB; IHC; ICC; IP.
MAB190Hu22 Monoclonal Antibody to Interleukin 19 (IL19) WB; IHC; ICC; IP.
MAB190Hu21 Monoclonal Antibody to Interleukin 19 (IL19) WB
MAB190Hu24 Monoclonal Antibody to Interleukin 19 (IL19) WB; IHC
MAB190Hu26 Monoclonal Antibody to Interleukin 19 (IL19) WB; IHC; ICC; IP.
LAB190Hu76 Biotin-Linked Monoclonal Antibody to Interleukin 19 (IL19) WB; IHC; ICC.
MAB190Hu23 Monoclonal Antibody to Interleukin 19 (IL19) WB
MAB190Hu25 Monoclonal Antibody to Interleukin 19 (IL19) WB; IHC; ICC; IP.
MAB190Hu27 Monoclonal Antibody to Interleukin 19 (IL19) WB; IHC; ICC; IP.
MAB190Hu28 Monoclonal Antibody to Interleukin 19 (IL19) WB; IHC; ICC; IP.
MAB190Hu29 Monoclonal Antibody to Interleukin 19 (IL19) WB; IHC; ICC; IP.
Assay Kits SEB190Hu ELISA Kit for Interleukin 19 (IL19) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB190Hu CLIA Kit for Interleukin 19 (IL19) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB190Mu01 Recombinant Interleukin 19 (IL19) Positive Control; Immunogen; SDS-PAGE; WB.
RPB190Mu02 Recombinant Interleukin 19 (IL19) Positive Control; Immunogen; SDS-PAGE; WB.
EPB190Mu61 Eukaryotic Interleukin 19 (IL19) Positive Control; Immunogen; SDS-PAGE; WB.
APB190Mu61 Active Interleukin 19 (IL19) Cell culture; Activity Assays.
Antibodies PAB190Mu01 Polyclonal Antibody to Interleukin 19 (IL19) WB; IHC; ICC; IP.
PAB190Mu02 Polyclonal Antibody to Interleukin 19 (IL19) WB; IHC; ICC; IP.
Assay Kits SEB190Mu ELISA Kit for Interleukin 19 (IL19) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB190Mu CLIA Kit for Interleukin 19 (IL19) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB190Ra01 Recombinant Interleukin 19 (IL19) Positive Control; Immunogen; SDS-PAGE; WB.
EPB190Ra61 Eukaryotic Interleukin 19 (IL19) Positive Control; Immunogen; SDS-PAGE; WB.
APB190Ra61 Active Interleukin 19 (IL19) Cell culture; Activity Assays.
Antibodies PAB190Ra01 Polyclonal Antibody to Interleukin 19 (IL19) WB; IHC; ICC; IP.
MAB190Ra21 Monoclonal Antibody to Interleukin 19 (IL19) WB; IHC; ICC; IP.
Assay Kits SEB190Ra ELISA Kit for Interleukin 19 (IL19) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB190Ra CLIA Kit for Interleukin 19 (IL19) Chemiluminescent immunoassay for Antigen Detection.
  1. "Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homolog of human interleukin-10 (IL-10)."Genes Immun. 1:442-450(2000) [PubMed] [Europe PMC] [Abstract]
  2. "IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha."J. Immunol. 169:4288-4297(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site."BMC Genomics 10:518-518(2009) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of interleukin-19 defines a new subfamily of helical cytokines."J. Biol. Chem. 278:3308-3313(2003) [PubMed] [Europe PMC] [Abstract]