Interleukin 19 (IL19)
[Edit]MDA1; ZMDA1, IL-10C, NG.1; Melanoma Differentiation Associated Protein-Like Protein
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Interleukin-19 is a cytokine that belongs to the IL-10 family of cytokines along with several other interleukins including IL-10, IL-20, IL-22, IL-24, IL-26, and several virus-encoded cytokines. It signals through the same cell surface receptor (IL-20R) that is used by IL-20 and IL-24. The IL-19 gene is expressed in resting monocytes and B cells. It is up-regulated in monocytes following stimulation with GM-CSF or lipopolysaccharide.
The predicted 177-amino acid protein contains a signal peptide, 2 potential N-linked glycosylation sites, and 4 conserved cysteine residues necessary for correct folding of the IL10 monomer. IL19 shares 82% identity with IL10 in the hydrophobic core, but only 53% similarity in the putative IL10 receptor-alpha (IL10RA)-interacting residues.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB190Mu01 | Recombinant Interleukin 19 (IL19) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB190Mu02 | Recombinant Interleukin 19 (IL19) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPB190Mu61 | Eukaryotic Interleukin 19 (IL19) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APB190Mu61 | Active Interleukin 19 (IL19) | Cell culture; Activity Assays. | |
| Antibodies | PAB190Mu01 | Polyclonal Antibody to Interleukin 19 (IL19) | WB; IHC; ICC; IP. |
| PAB190Mu02 | Polyclonal Antibody to Interleukin 19 (IL19) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB190Mu | ELISA Kit for Interleukin 19 (IL19) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB190Mu | CLIA Kit for Interleukin 19 (IL19) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB190Ra01 | Recombinant Interleukin 19 (IL19) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPB190Ra61 | Eukaryotic Interleukin 19 (IL19) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APB190Ra61 | Active Interleukin 19 (IL19) | Cell culture; Activity Assays. | |
| Antibodies | PAB190Ra01 | Polyclonal Antibody to Interleukin 19 (IL19) | WB; IHC; ICC; IP. |
| MAB190Ra21 | Monoclonal Antibody to Interleukin 19 (IL19) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB190Ra | ELISA Kit for Interleukin 19 (IL19) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB190Ra | CLIA Kit for Interleukin 19 (IL19) | Chemiluminescent immunoassay for Antigen Detection. |
- "Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homolog of human interleukin-10 (IL-10)."Genes Immun. 1:442-450(2000) [PubMed] [Europe PMC] [Abstract]
- "IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha."J. Immunol. 169:4288-4297(2002) [PubMed] [Europe PMC] [Abstract]
- "Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site."BMC Genomics 10:518-518(2009) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of interleukin-19 defines a new subfamily of helical cytokines."J. Biol. Chem. 278:3308-3313(2003) [PubMed] [Europe PMC] [Abstract]