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c-Jun N-terminal Kinase 1 (JNK1)

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MAPK8; JNK1A2; JNK21B1/2; PRKM8; SAPK1; JUN N-Terminal Kinase; Stress-activated protein kinase 1c; Mitogen Activated Protein Kinase 8

c-Jun N-terminal Kinase 1 (JNK1)
CCC B156
HGNC 6881
MGI 1346861
PubMed 18222916
RGD 621506
UniProt P45983
Wiki MAPK8

Mitogen-activated protein kinase 8 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.

This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB156Hu01 Recombinant c-Jun N-terminal Kinase 1 (JNK1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB156Hu02 Recombinant c-Jun N-terminal Kinase 1 (JNK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB156Hu01 Polyclonal Antibody to c-Jun N-terminal Kinase 1 (JNK1) WB; IHC; ICC/IF
Assay Kits n/a CLIA Kit for c-Jun N-terminal Kinase 1 (JNK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for c-Jun N-terminal Kinase 1 (JNK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB156Mu01 Recombinant c-Jun N-terminal Kinase 1 (JNK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB156Mu01 Polyclonal Antibody to c-Jun N-terminal Kinase 1 (JNK1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for c-Jun N-terminal Kinase 1 (JNK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for c-Jun N-terminal Kinase 1 (JNK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB156Ra01 Recombinant c-Jun N-terminal Kinase 1 (JNK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB156Ra01 Polyclonal Antibody to c-Jun N-terminal Kinase 1 (JNK1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for c-Jun N-terminal Kinase 1 (JNK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for c-Jun N-terminal Kinase 1 (JNK1) ELISA Kit Customized Service Offer
  1. "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain."Cell 76:1025-1037(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Selective interaction of JNK protein kinase isoforms with transcription factors."EMBO J. 15:2760-2770(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms."Science 267:682-685(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7."Biochem. J. 352:145-154(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death."EMBO J. 19:2958-2968(2000) [PubMed] [Europe PMC] [Abstract]
  9. "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis."J. Biol. Chem. 278:9195-9202(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein."Biochem. J. 389:73-82(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26."Mol. Cell. Biol. 26:3282-3294(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation."Cancer Res. 67:8725-8735(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK-and caspase-dependent nuclear localization is a requirement for membrane blebbing."J. Biol. Chem. 282:6484-6493(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1."Mol. Cell. Biol. 27:2861-2869(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1."Anal. Biochem. 376:115-121(2008) [PubMed] [Europe PMC] [Abstract]
  16. "JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy."Mol. Cell 30:678-688(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of SCCA1 and insight about the interaction with JNK1."Biochem. Biophys. Res. Commun. 380:143-147(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  21. "JNK1 phosphorylates SIRT1 and promotes its enzymatic activity."PLoS ONE 4:E8414-E8414(2009) [PubMed] [Europe PMC] [Abstract]
  22. "JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis."Cell Death Dis. 1:E29-E29(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "A critical step for JNK activation: isomerization by the prolyl isomerase Pin1."Cell Death Differ. 19:153-161(2012) [PubMed] [Europe PMC] [Abstract]
  25. "JNK regulates the photic response of the mammalian circadian clock."EMBO Rep. 13:455-461(2012) [PubMed] [Europe PMC] [Abstract]
  26. "Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells."Int. J. Biochem. Cell Biol. 43:409-415(2011) [PubMed] [Europe PMC] [Abstract]
  27. "Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis."Mol. Biol. Cell 22:117-127(2011) [PubMed] [Europe PMC] [Abstract]
  28. "JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress."Mol. Cell 44:62-71(2011) [PubMed] [Europe PMC] [Abstract]
  29. "Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125."EMBO J. 23:2185-2195(2004) [PubMed] [Europe PMC] [Abstract]
  30. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]