≡

Cluster Of Differentiation 24 (CD24)

[Edit]

Small Cell Lung Carcinoma Cluster 4 Antigen

Cluster Of Differentiation 24 (CD24)
CCC B143
HGNC 1645
PubMed 22926560
UniProt P25063
Wiki CD24

CD24 is a cell adhesion molecule. CD24 is a glycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. It is expressed in many B-lineage cells and on mature granulocytes.

However, studies with monoclonal antibodies indicate that most other hematopoietic cells, including T cells, monocytes, red blood cells, and platelets, seem not to express the CD24 antigen. CD24 has been implicated in both activation and differentiation of B lymphocytes because its expression pattern changes at critical times during B-cell development.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB143Hu01 Recombinant Cluster Of Differentiation 24 (CD24) Positive Control; Immunogen; SDS-PAGE; WB.
RPB143Hu02 Recombinant Cluster Of Differentiation 24 (CD24) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB143Hu01 Polyclonal Antibody to Cluster Of Differentiation 24 (CD24) WB; IHC; ICC; IP.
MAB143Hu22 Monoclonal Antibody to Cluster Of Differentiation 24 (CD24) WB; IHC; ICC; IP.
LAB143Hu71 Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 24 (CD24) WB; IHC; ICC.
Assay Kits SEB143Hu ELISA Kit for Cluster Of Differentiation 24 (CD24) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor."J. Immunol. 147:1412-1416(1991) [PubMed] [Europe PMC] [Abstract]
  2. "CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas."Cancer Res. 52:5264-5270(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mapping of CD24 and homologous sequences to multiple chromosomal loci."Genomics 22:154-161(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line."Biochem. Biophys. Res. Commun. 225:384-391(1996) [PubMed] [Europe PMC] [Abstract]
  6. "CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system."J. Immunol. 166:5567-5577(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21."Cytogenet. Cell Genet. 70:119-125(1995) [PubMed] [Europe PMC] [Abstract]
  8. "CD24 is a genetic modifier for risk and progression of multiple sclerosis."Proc. Natl. Acad. Sci. U.S.A. 100:15041-15046(2003) [PubMed] [Europe PMC] [Abstract]
  9. ErratumProc. Natl. Acad. Sci. U.S.A. 102:8392-8392(2005)