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Complement Receptor 1, Erythrocyte (CR1)

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CD35; C3BR; KN; C3b/C4b Receptor,Including Knops Blood Group System; Immune Adherence Receptor

Complement Receptor 1, Erythrocyte (CR1)
CCC B123
HGNC 2334
PubMed 16360013
UniProt P17927
Wiki CR1

Erythrocyte complement receptor 1 is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein.

The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB123Hu01 Recombinant Complement Receptor 1, Erythrocyte (CR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB123Hu01 Polyclonal Antibody to Complement Receptor 1, Erythrocyte (CR1) WB; IHC; ICC; IP.
MAB123Hu22 Monoclonal Antibody to Complement Receptor 1, Erythrocyte (CR1) WB; IHC; ICC; IP.
LAB123Hu71 Biotin-Linked Polyclonal Antibody to Complement Receptor 1, Erythrocyte (CR1) WB; IHC; ICC.
Assay Kits SEB123Hu ELISA Kit for Complement Receptor 1, Erythrocyte (CR1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Structure of the gene for the F allele of complement receptor type 1 and sequence of the coding region unique to the S allele."J. Immunol. 151:6214-6224(1993) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele."J. Exp. Med. 169:847-863(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of an alternative polyadenylation site in the human C3b/C4b receptor (complement receptor type 1) transcriptional unit and prediction of a secreted form of complement receptor type 1."J. Exp. Med. 168:1255-1270(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins."J. Exp. Med. 165:1095-1112(1987) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a partial cDNA clone for the human receptor for complement fragments C3b/C4b."Proc. Natl. Acad. Sci. U.S.A. 82:7711-7715(1985) [PubMed] [Europe PMC] [Abstract]
  8. "Structural polymorphisms of complement receptor 1 (CR1) in systemic lupus erythematosus (SLE) patients and normal controls of three ethnic groups."Clin. Exp. Immunol. 105:302-305(1996) [PubMed] [Europe PMC] [Abstract]
  9. "A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria."Proc. Natl. Acad. Sci. U.S.A. 101:272-277(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1."Blood 97:2879-2885(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Expansion of the Knops blood group system and subdivision of Sl(a)."Transfusion 42:251-256(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor."Cell 108:769-780(2002) [PubMed] [Europe PMC] [Abstract]