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Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1)

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CD39; ATPDase; NTPDase-1; Ecto-ATP diphosphohydrolase 1; Ecto-apyrase; Lymphoid cell activation antigen

Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1)
CCC B118
HGNC 3363
MGI 102805
RGD 69265
UniProt P49961

Endothelial cells have the ability to regulate platelet activation, in part by the surface expression of ATP diphosphohydrolase (ATPDase; EC 3.6.1.5). ATPDase hydrolyzes extracellular ATP and ADP to AMP, which is further converted to adenosine by another enzyme, 5-prime nucleotidase. ADP is a powerful agonist for platelet recruitment and adhesion; adenosine is an antagonist of these processes. 

CD39 was found to have both immunologic identity to, and functional characteristics of, vascular ATPDase. By Northern blot analysis, Chadwick and Frischauf (1998) found that CD39 is expressed as a major 3.2- and a minor 3.6-kb mRNA in several tissues. Additional bands were observed in a few tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB118Hu01 Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB118Hu01 Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IP.
Assay Kits SEB118Hu ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB118Mu01 Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB118Mu01 Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB118Ra01 Recombinant Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB118Ra01 Polyclonal Antibody to Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ectonucleoside Triphosphate Diphosphohydrolase 1 (ENTPD1) ELISA Kit Customized Service Offer
  1. "The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization."J. Immunol. 153:3574-3583(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Loss of ATP diphosphohydrolase activity with endothelial cell activation."J. Exp. Med. 185:153-163(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The cDNA cloning of human placental ecto-ATP diphosphohydrolases I and II."FEBS Lett. 453:335-340(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Purification and properties of human placental ATP diphosphohydrolase."Eur. J. Biochem. 234:66-74(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation."Int. J. Hematol. 68:297-310(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Identification and characterization of CD39/vascular ATP diphosphohydrolase."J. Biol. Chem. 271:33116-33122(1996) [PubMed] [Europe PMC] [Abstract]
  10. "CD39 is an ecto-(Ca2+,Mg2+)-apyrase."J. Biol. Chem. 271:9898-9901(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae."J. Biol. Chem. 275:2057-2062(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders." Science 343:506-511(2014) [PubMed] [Europe PMC] [Abstract]