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Coagulation Factor XIII A1 Polypeptide (F13A1)

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F13-A1; FXIIIA1; Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain; Coagulation factor XIII A chain

Coagulation Factor XIII A1 Polypeptide (F13A1)
CCC B094
HGNC 3531
MGI 1921395
PubMed 22565190
RGD 621495
UniProt P00488
Wiki F13A1

coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB094Hu01 Recombinant Coagulation Factor XIII A1 Polypeptide (F13A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB094Hu01 Polyclonal Antibody to Coagulation Factor XIII A1 Polypeptide (F13A1) WB,IHC,ICC/IF
MAB094Hu22 Monoclonal Antibody to Coagulation Factor XIII A1 Polypeptide (F13A1) WB; IHC; ICC; IP.
Assay Kits SEB094Hu ELISA Kit for Coagulation Factor XIII A1 Polypeptide (F13A1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB094Mu01 Recombinant Coagulation Factor XIII A1 Polypeptide (F13A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB094Mu01 Polyclonal Antibody to Coagulation Factor XIII A1 Polypeptide (F13A1) WB; IHC; ICC; IP.
Assay Kits SEB094Mu ELISA Kit for Coagulation Factor XIII A1 Polypeptide (F13A1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB094Ra01 Recombinant Coagulation Factor XIII A1 Polypeptide (F13A1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB094Ra02 Recombinant Coagulation Factor XIII A1 Polypeptide (F13A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB094Ra01 Polyclonal Antibody to Coagulation Factor XIII A1 Polypeptide (F13A1) WB; IHC; ICC; IP.
MAB094Ra21 Monoclonal Antibody to Coagulation Factor XIII A1 Polypeptide (F13A1) WB; IHC; ICC; IP.
Assay Kits SEB094Ra ELISA Kit for Coagulation Factor XIII A1 Polypeptide (F13A1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Characterization of cDNA coding for human factor XIIIa."Proc. Natl. Acad. Sci. U.S.A. 83:8024-8028(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the gene for the a subunit of human factor XIII (plasma transglutaminase), a blood coagulation factor."Proc. Natl. Acad. Sci. U.S.A. 85:5829-5833(1988) [PubMed] [Europe PMC] [Abstract]
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  7. "Amino acid sequence studies on factor XIII and the peptide released during its activation by thrombin."Biochemistry 13:750-756(1974) [PubMed] [Europe PMC] [Abstract]
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII."Proc. Natl. Acad. Sci. U.S.A. 91:7296-7300(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Structural evidence that the activation peptide is not released upon thrombin cleavage of factor XIII."Thromb. Res. 78:389-397(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Two non-proline cis peptide bonds may be important for factor XIII function."FEBS Lett. 423:291-296(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by X-ray crystallography."J. Biol. Chem. 274:4917-4923(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular basis for subtypic differences of the 'a' subunit of coagulation factor XIII with description of the genesis of the subtypes."Hum. Genet. 94:129-135(1994) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of a point mutation in factor XIII A subunit deficiency."Blood 80:937-941(1992) [PubMed] [Europe PMC] [Abstract]
  15. "The Val34Leu polymorphism in the A subunit of coagulation factor XIII contributes to the large normal range in activity and demonstrates that the activation peptide plays a role in catalytic activity."Blood 92:2766-2770(1998) [PubMed] [Europe PMC] [Abstract]
  16. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  17. ErratumNat. Genet. 23:373-373(1999)