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Polymeric Immunoglobulin Receptor (PIGR)

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SC; Secretory Component; Hepatocellular carcinoma-associated protein TB6

Polymeric Immunoglobulin Receptor (PIGR)
CCC B074
HGNC 8968
MGI 103080
PubMed 23809084
RGD 3328
UniProt P01833
Wiki PIGR

Polymeric immunoglobulin receptor is a Fc receptor which facilitates the secretion of IgA and IgM. The poly-Ig receptor is expressed on several glandular epithelia including those of liver and breast. It mediates transcellular transport of polymeric immunoglobulin molecules.

It is a member of the immunoglobulin superfamily (Hood et al., 1985). The receptor has 5 units with homology to the variable (V) units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB074Hu01 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Hu02 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB074Hu01 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC
MAB074Hu22 Monoclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB
PAB074Hu02 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC
LAB074Hu71 Biotin-Linked Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB
MAB074Hu21 Monoclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB
MAB074Hu23 Monoclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB
MAB074Hu24 Monoclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB
Assay Kits SEB074Hu ELISA Kit for Polymeric Immunoglobulin Receptor (PIGR) Enzyme-linked immunosorbent assay for Antigen Detection.
AEB074Hu ELISA Kit for Anti-Polymeric Immunoglobulin Receptor Antibody (Anti-PIGR) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB074Mu01 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Mu03 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Mu02 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB074Mu01 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) IHC
PAB074Mu02 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) IHC
PAB074Mu03 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC
LAB074Mu71 Biotin-Linked Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC.
Assay Kits SEB074Mu ELISA Kit for Polymeric Immunoglobulin Receptor (PIGR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB074Ra01 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Ra02 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Ra03 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB074Ra01 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) IHC
PAB074Ra02 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC; IP.
LAB074Ra71 Biotin-Linked Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC; ICC.
PAB074Ra03 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB
Assay Kits n/a CLIA Kit for Polymeric Immunoglobulin Receptor (PIGR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymeric Immunoglobulin Receptor (PIGR) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB074Bo01 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Bo03 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
RPB074Bo02 Recombinant Polymeric Immunoglobulin Receptor (PIGR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB074Bo01 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) IHC; ICC/IF
PAB074Bo02 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC
PAB074Bo03 Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB; IHC
LAB074Bo71 Biotin-Linked Polyclonal Antibody to Polymeric Immunoglobulin Receptor (PIGR) WB
Assay Kits SEB074Bo ELISA Kit for Polymeric Immunoglobulin Receptor (PIGR) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization."Hum. Genet. 87:642-648(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)."Eur. J. Immunol. 22:2309-2315(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues."Biochem. Biophys. Res. Commun. 158:783-789(1989) [PubMed] [Europe PMC] [Abstract]
  5. "The primary structure of human free secretory component and the arrangement of disulfide bonds."Hoppe-Seyler's Z. Physiol. Chem. 365:1489-1495(1984) [PubMed] [Europe PMC] [Abstract]
  6. "Determination of the molecular structure of the human free secretory component."Biol. Chem. Hoppe-Seyler 372:119-128(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor."FEBS Lett. 410:443-446(1997) [PubMed] [Europe PMC] [Abstract]
  8. "A proteomic analysis of human bile."Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor."Structure 12:1925-1935(2004) [PubMed] [Europe PMC] [Abstract]