Transcriptional Activator Myb (c-Myb)

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MYB; Cmyb; C-Myb_CDS; Efg; Proto-oncogene c-Mybl; V-Myb Myeloblastosis Viral Oncogene Homolog

Transcriptional Activator Myb (c-Myb)

The c-Myb protein is a DNA-binding transcriptional regulator with a highly conserved DNA-binding domain composed of three ‘Myb repeats’ resembling consecutive homeodomain-like or helix–turn–helix-like motifs. The proto-oncoprotein c-Myb is the normal counterpart to the oncogenic v-Myb proteins expressed by two avian leukemia viruses, avian myeloblastosis virus and E26. Both viruses induce acute myeloid leukemias in birds and transform immature myeloid cells in tissue culture. In birds and mice, the c-myb gene is a common target for retroviral insertions leading to myeloid and lymphoid tumors. Interestingly, transgenic overexpression of normal c-Myb does not induce tumors in mice, although transgenic v-Myb can induce leukemias after a long latency, indicating that v-Myb-induced leukemogenesis requires additional secondary mutations.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB055Hu01 Recombinant Transcriptional Activator Myb (c-Myb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB055Hu01 Polyclonal Antibody to Transcriptional Activator Myb (c-Myb) WB
Assay Kits n/a CLIA Kit for Transcriptional Activator Myb (c-Myb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcriptional Activator Myb (c-Myb) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB055Mu01 Recombinant Transcriptional Activator Myb (c-Myb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB055Mu01 Polyclonal Antibody to Transcriptional Activator Myb (c-Myb) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Transcriptional Activator Myb (c-Myb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transcriptional Activator Myb (c-Myb) ELISA Kit Customized Service Offer
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  12. "HIPK1 interacts with c-Myb and modulates its activity through phosphorylation."Biochem. Biophys. Res. Commun. 388:150-154(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."J. Exp. Med. 209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]