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Ubiquitin Activating Enzyme E1 Like Protein (UBE1L)

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UBE1-L; D8; UBE2; UBA7; Ubiquitin Like Modifier Activating Enzyme 7

Ubiquitin Activating Enzyme E1 Like Protein (UBE1L)
CCC B027
HGNC 12471
MGI 1349462
PubMed 19074853
RGD 1308323
UniProt P41226
Wiki UBE1L

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family.

Ubiquitin-like modifier-activating enzyme 7 is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB027Hu01 Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB027Hu01 Polyclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) WB; IHC; ICC; IP.
MAB027Hu22 Monoclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB027Mu01 Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB027Mu01 Polyclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB027Ra01 Recombinant Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB027Ra01 Polyclonal Antibody to Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Activating Enzyme E1 Like Protein (UBE1L) ELISA Kit Customized Service Offer
  1. "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme."Proc. Natl. Acad. Sci. U.S.A. 90:6071-6075(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The genomic structure of the human UBE1L gene."Gene Expr. 4:163-175(1995) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein."EMBO J. 20:362-371(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo."J. Virol. 79:13974-13983(2005) [PubMed] [Europe PMC] [Abstract]
  7. "ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells."Proc. Natl. Acad. Sci. U.S.A. 107:2253-2258(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Covalent protein modification with ISG15 via a conserved cysteine in the hinge region."PLoS ONE 7:E38294-E38294(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]