Alpha-lactalbumin is an important whey protein in cow's milk (~1 g/l), and is also present in the milk of many other mammalian species. In primates, alpha-lactalbumin expression is upregulated in response to the hormone prolactin and increases the production of lactose. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta-1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transferring galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB018Hu01 | Recombinant Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
NPB018Hu01 | Native Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAB018Hu01 | Polyclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. |
MAB018Hu22 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. | |
MAB018Hu21 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. | |
MAB018Hu23 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. | |
MAB018Hu27 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. | |
MAB018Hu25 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. | |
MAB018Hu29 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. | |
Assay Kits | SEB018Hu | ELISA Kit for Alpha-Lactalbumin (aLA) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB018Mu01 | Recombinant Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB018Mu01 | Polyclonal Antibody to Alpha-Lactalbumin (aLA) | WB |
Assay Kits | n/a | CLIA Kit for Alpha-Lactalbumin (aLA) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Alpha-Lactalbumin (aLA) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB018Ra01 | Recombinant Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB018Ra01 | Polyclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Alpha-Lactalbumin (aLA) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Alpha-Lactalbumin (aLA) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB018Bo01 | Recombinant Alpha-Lactalbumin (aLA) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB018Bo01 | Polyclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. |
MAB018Bo21 | Monoclonal Antibody to Alpha-Lactalbumin (aLA) | WB; IHC; ICC; IP. | |
Assay Kits | SEB018Bo | ELISA Kit for Alpha-Lactalbumin (aLA) | Enzyme-linked immunosorbent assay for Antigen Detection. |
HEB018Bo | High Sensitive ELISA Kit for Alpha-Lactalbumin (aLA) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Comparison of the nucleotide sequence of cloned human and guinea-pig pre-alpha-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene."Nucleic Acids Res. 10:3503-3515(1982) [PubMed] [Europe PMC] [Abstract]
- "Organization and sequence of the human alpha-lactalbumin gene."Biochem. J. 242:735-742(1987) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The complete amino-acid sequence of human alpha-lactalbumin."Eur. J. Biochem. 27:65-86(1972) [PubMed] [Europe PMC] [Abstract]
- "Identification of a new molecular form of human alpha-lactalbumin."J. Dairy Res. 59:425-429(1992) [PubMed] [Europe PMC] [Abstract]
- "An unusual glycosylation site in alpha-lactalbumin from human milk."Protein Sci. 4 Suppl. 1:119-119(1995)
- "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of human alpha-lactalbumin at 1.7-A resolution."J. Mol. Biol. 221:571-581(1991) [PubMed] [Europe PMC] [Abstract]
- "Alpha-lactalbumin possesses a distinct zinc binding site."J. Biol. Chem. 268:19292-19298(1993) [PubMed] [Europe PMC] [Abstract]
- "Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin."Biochemistry 37:4767-4772(1998) [PubMed] [Europe PMC] [Abstract]
- "Crystallographic evaluation of internal motion of human alpha-lactalbumin refined by full-matrix least-squares method."J. Mol. Biol. 287:347-358(1999) [PubMed] [Europe PMC] [Abstract]
- "Detection of a single nucleotide polymorphism in the human alpha-lactalbumin gene: implications for human milk proteins."J. Nutr. Biochem. 16:272-278(2005) [PubMed] [Europe PMC] [Abstract]