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Aprotinin is used as medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown of blood clots. The aim in its use is to decrease the need for blood transfusions during surgery, as well as end-organ damage due to hypotension (low blood pressure) as a result of marked blood loss. The drug was temporarily withdrawn worldwide in 2007 after studies suggested that its use increased the risk of complications or death; this was confirmed by follow-up studies.
Aprotinin is a monomeric (single-chain) globular polypeptide derived from bovine lung tissue; it has a molecular weight of 6512 and consists of 16 different amino acids arranged in a chain of 58 amino acid residues.
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA968Po01 | Recombinant Aprotinin (AP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA968Po61 | Eukaryotic Aprotinin (AP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA968Po61 | Active Aprotinin (AP) | Cell culture; Activity Assays. | |
| RPA968Po02 | Recombinant Aprotinin (AP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPA968Po03 | Recombinant Aprotinin (AP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPA968Po62 | Eukaryotic Aprotinin (AP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA968Po62 | Active Aprotinin (AP) | Cell culture; Activity Assays. | |
| Antibodies | PAA968Po01 | Polyclonal Antibody to Aprotinin (AP) | WB; IHC; ICC; IP. |
| MAA968Po21 | Monoclonal Antibody to Aprotinin (AP) | WB; IHC; ICC; IP. | |
| Assay Kits | CEA968Po | ELISA Kit for Aprotinin (AP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA968Bo01 | Recombinant Aprotinin (AP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA968Bo01 | Active Aprotinin (AP) | Cell culture; Activity Assays. | |
| NPA968Bo01 | Native Aprotinin (AP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA968Bo61 | Active Aprotinin (AP) | Cell culture; Activity Assays. | |
| EPA968Bo61 | Eukaryotic Aprotinin (AP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA968Bo62 | Active Aprotinin (AP) | Cell culture; Activity Assays. | |
| EPA968Bo62 | Eukaryotic Aprotinin (AP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA968Bo01 | Polyclonal Antibody to Aprotinin (AP) | WB; IHC; ICC; IP. |
| LAA968Bo71 | Biotin-Linked Polyclonal Antibody to Aprotinin (AP) | WB; IHC; ICC. | |
| MAA968Bo21 | Monoclonal Antibody to Aprotinin (AP) | WB; IHC; ICC; IP. | |
| Assay Kits | CEA968Bo | ELISA Kit for Aprotinin (AP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| CCA968Bo | CLIA Kit for Aprotinin (AP) | Chemiluminescent immunoassay for Antigen Detection. |
- "Purification and characterization of aprotinin from porcine lungs."Biotechnol. Lett. 0:0-0(2008).