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Intelectin 1 (ITLN1)

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HL1; INTL; ITLN; LFR; HIntL; Omentin; Intelectin 1,Galactofuranose Binding; Intestinal Lactoferrin Receptor;Endothelial lectin HL-1

Intelectin 1 (ITLN1)
CCC A933
HGNC 18259
MGI 3057189
PubMed 22801013
RGD 1561048
UniProt Q8WWA0
Wiki ITLN1

Omentin is a protein expressed and secreted from visceral but not subcutaneous adipose tissue that increases insulin sensitivity in human adipocytes. To determine the impact of obesity-dependent insulin resistance on the regulation of two omentin isoforms, gene expression and plasma levels were measured in lean, overweight, and obese subjects.

Intelectin-1 is a 40 kDa Ca-dependent galactofuranose-binding lectin that is not a C-type lectin. Human ITLN-1 exists as a disulfide-linked glycosylated homotrimer. Mouse ITLN-1 is unglycosylated and a monomer. Mature human ITLN-1 is 82% aa identical to mouse ITLN-1. Human ITLN-1 shows one alternate start site at Met72, and a splice form that contains a 32 aa substitution for aa 264-313.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA933Hu01 Recombinant Intelectin 1 (ITLN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA933Hu01 Polyclonal Antibody to Intelectin 1 (ITLN1) WB; IHC
MAA933Hu22 Monoclonal Antibody to Intelectin 1 (ITLN1) WB; IHC; ICC; IP.
Assay Kits SEA933Hu ELISA Kit for Intelectin 1 (ITLN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA933Mu01 Recombinant Intelectin 1 (ITLN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA933Mu02 Recombinant Intelectin 1 (ITLN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA933Mu01 Polyclonal Antibody to Intelectin 1 (ITLN1) WB; IHC; ICC; IP.
LAA933Mu71 Biotin-Linked Polyclonal Antibody to Intelectin 1 (ITLN1) WB; IHC; ICC.
PAA933Mu02 Polyclonal Antibody to Intelectin 1 (ITLN1) WB; IHC; ICC; IP.
Assay Kits SEA933Mu ELISA Kit for Intelectin 1 (ITLN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA933Ra01 Recombinant Intelectin 1 (ITLN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA933Ra01 Polyclonal Antibody to Intelectin 1 (ITLN1) WB; IHC; ICC; IP.
LAA933Ra71 Biotin-Linked Polyclonal Antibody to Intelectin 1 (ITLN1) WB; IHC; ICC.
MAA933Ra21 Monoclonal Antibody to Intelectin 1 (ITLN1) WB; IHC; ICC; IP.
Assay Kits SEA933Ra ELISA Kit for Intelectin 1 (ITLN1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning and functional expression of a human intestinal lactoferrin receptor."Biochemistry 40:15771-15779(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Human homologs of the Xenopus oocyte cortical granule lectin XL35."Glycobiology 11:65-73(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall."J. Biol. Chem. 276:23456-23463(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins."Comp. Biochem. Physiol. 137A:115-129(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action."Am. J. Physiol. 290:E1253-E1261(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Differential structure and activity between human and mouse intelectin-1: human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomer."Glycobiology 17:1045-1051(2007) [PubMed] [Europe PMC] [Abstract]