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Protease Activated Receptor 2 (PAR2)

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F2RL1; F2-RL1; GPR11; PAR2; Coagulation Factor II(thrombin)receptor-Like 1; G-protein coupled receptor 11; Thrombin receptor-like 1

Protease Activated Receptor 2 (PAR2)
CCC A852
HGNC 3538
MGI 101910
PubMed 15320742
RGD 620866
UniProt P55085
Wiki PAR2

PAR2 is a member of the large family of 7-transmembrane receptors that couple to guanosine-nucleotide-binding proteins. PAR2 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. Additionally, these receptors can be activated by exogenous proteases, such as house dust mite protein Der P9. These receptors can also be activated non-protealytically, by exogenous peptide sequences that mimic the final amino acids of the tethered ligand. Recently, potent and selective small molecule agonists for these receptors have also been discovered but are not currently widely available.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA852Hu01 Recombinant Protease Activated Receptor 2 (PAR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA852Hu01 Polyclonal Antibody to Protease Activated Receptor 2 (PAR2) WB; IHC; ICC; IP.
MAA852Hu22 Monoclonal Antibody to Protease Activated Receptor 2 (PAR2) WB; IHC; ICC; IP.
Assay Kits SEA852Hu ELISA Kit for Protease Activated Receptor 2 (PAR2) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA852Hu CLIA Kit for Protease Activated Receptor 2 (PAR2) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA852Mu01 Recombinant Protease Activated Receptor 2 (PAR2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA852Mu02 Recombinant Protease Activated Receptor 2 (PAR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA852Mu01 Polyclonal Antibody to Protease Activated Receptor 2 (PAR2) WB; IHC; ICC; IP.
MAA852Mu22 Monoclonal Antibody to Protease Activated Receptor 2 (PAR2) WB; IHC; ICC; IP.
PAA852Mu02 Polyclonal Antibody to Protease Activated Receptor 2 (PAR2) WB; IHC; ICC; IP.
Assay Kits SEA852Mu ELISA Kit for Protease Activated Receptor 2 (PAR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA852Ra01 Recombinant Protease Activated Receptor 2 (PAR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA852Ra01 Polyclonal Antibody to Protease Activated Receptor 2 (PAR2) WB; IHC; ICC; IP.
MAA852Ra21 Monoclonal Antibody to Protease Activated Receptor 2 (PAR2) WB; IHC; ICC; IP.
Assay Kits SEA852Ra ELISA Kit for Protease Activated Receptor 2 (PAR2) Enzyme-linked immunosorbent assay for Antigen Detection.
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  8. "Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1."J. Biol. Chem. 275:13502-13509(2000) [PubMed] [Europe PMC] [Abstract]
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  10. "Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates."J. Biol. Chem. 275:26333-26342(2000) [PubMed] [Europe PMC] [Abstract]
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  19. "Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo."FASEB J. 17:1871-1885(2003) [PubMed] [Europe PMC] [Abstract]
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  22. "Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices."J. Leukoc. Biol. 76:388-398(2004) [PubMed] [Europe PMC] [Abstract]
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  25. "A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis."Proc. Natl. Acad. Sci. U.S.A. 102:8363-8368(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Abrogation of bronchial eosinophilic inflammation and attenuated eotaxin content in protease-activated receptor 2-deficient mice."J. Pharmacol. Sci. 98:99-102(2005) [PubMed] [Europe PMC] [Abstract]
  27. "PAR2 activation interrupts E-cadherin adhesion and compromises the airway epithelial barrier: protective effect of beta-agonists."Am. J. Physiol. 291:L628-L635(2006) [PubMed] [Europe PMC] [Abstract]
  28. "Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway."Blood 107:4440-4448(2006) [PubMed] [Europe PMC] [Abstract]
  29. "Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis."J. Exp. Med. 203:425-435(2006) [PubMed] [Europe PMC] [Abstract]
  30. "Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2."J. Biol. Chem. 282:20634-20646(2007) [PubMed] [Europe PMC] [Abstract]
  31. "p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking."J. Biol. Chem. 282:30246-30255(2007) [PubMed] [Europe PMC] [Abstract]
  32. "Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2."J. Immunol. 178:5237-5244(2007) [PubMed] [Europe PMC] [Abstract]
  33. "Chitinase activates protease-activated receptor-2 in human airway epithelial cells."Am. J. Respir. Cell Mol. Biol. 39:530-535(2008) [PubMed] [Europe PMC] [Abstract]
  34. "G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes."Cell. Signal. 20:1267-1274(2008) [PubMed] [Europe PMC] [Abstract]
  35. "Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity."J. Biol. Chem. 283:24314-24325(2008) [PubMed] [Europe PMC] [Abstract]
  36. "Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection."J. Immunol. 180:6903-6910(2008) [PubMed] [Europe PMC] [Abstract]
  37. "Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2."J. Biol. Chem. 284:28453-28466(2009) [PubMed] [Europe PMC] [Abstract]
  38. "Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization."J. Biol. Chem. 284:34444-34457(2009) [PubMed] [Europe PMC] [Abstract]
  39. "Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway."J. Immunol. 182:7795-7802(2009) [PubMed] [Europe PMC] [Abstract]
  40. "Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils."J. Immunol. 183:6708-6716(2009) [PubMed] [Europe PMC] [Abstract]
  41. "Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis."Ann. Rheum. Dis. 69:2051-2054(2010) [PubMed] [Europe PMC] [Abstract]
  42. "Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - a novel paradigm for G(q/11) linked GPCRs."Cell. Signal. 22:265-273(2010) [PubMed] [Europe PMC] [Abstract]
  43. "Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1."J. Biol. Chem. 285:34803-34812(2010) [PubMed] [Europe PMC] [Abstract]
  44. "Protease-activated receptor-2 (PAR(2)) in human periodontitis."J. Dent. Res. 89:948-953(2010) [PubMed] [Europe PMC] [Abstract]
  45. "Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo."Mucosal Immunol. 3:29-39(2010) [PubMed] [Europe PMC] [Abstract]
  46. "Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-gamma on human neutrophils and monocytes."Immunology 133:329-339(2011) [PubMed] [Europe PMC] [Abstract]
  47. "Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor triggered ERK1/2 activation, calcium signalling, and endocytosis."Biochem. J. 438:359-367(2011) [PubMed] [Europe PMC] [Abstract]