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Cholesteryl Ester Transfer Protein (CETP)

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LTP; Lipid Transfer Protein; Plasma Lipid Transfer Protein; Cholesterylester Transfer Protein

Cholesteryl Ester Transfer Protein (CETP)
CCC A814
HGNC 1869
PubMed 17055779
UniProt P11597
Wiki CETP

Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very low-density (VLDL) or low-density lipoproteins (LDL) and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa. Most of the time, however, CETP does a homoexchange, trading a triglyceride for a triglyceride or a cholesteryl ester for a cholesteryl ester.

Rare mutations leading to increased function of CETP have been linked to accelerated atherosclerosis. In contrast, a polymorphism (I405V) of the CETP gene leading to lower serum levels has also been linked to exceptional longevity

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA814Hu01 Recombinant Cholesteryl Ester Transfer Protein (CETP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA814Hu02 Recombinant Cholesteryl Ester Transfer Protein (CETP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA814Hu03 Recombinant Cholesteryl Ester Transfer Protein (CETP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA814Hu04 Recombinant Cholesteryl Ester Transfer Protein (CETP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA814Hu01 Polyclonal Antibody to Cholesteryl Ester Transfer Protein (CETP) WB; IHC; ICC; IP.
MAA814Hu22 Monoclonal Antibody to Cholesteryl Ester Transfer Protein (CETP) WB; IHC; ICC; IP.
PAA814Hu02 Polyclonal Antibody to Cholesteryl Ester Transfer Protein (CETP) WB; IHC; ICC; IP.
PAA814Hu03 Polyclonal Antibody to Cholesteryl Ester Transfer Protein (CETP) WB; IHC; ICC; IP.
LAA814Hu71 Biotin-Linked Polyclonal Antibody to Cholesteryl Ester Transfer Protein (CETP) WB; IHC; ICC.
Assay Kits SEA814Hu ELISA Kit for Cholesteryl Ester Transfer Protein (CETP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA814Rb01 Recombinant Cholesteryl Ester Transfer Protein (CETP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA814Rb02 Recombinant Cholesteryl Ester Transfer Protein (CETP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA814Rb52 Polyclonal Antibody to Cholesteryl Ester Transfer Protein (CETP) WB; IHC; ICC; IP.
PAA814Rb51 Polyclonal Antibody to Cholesteryl Ester Transfer Protein (CETP) WB; IHC; ICC; IP.
Assay Kits SEA814Rb ELISA Kit for Cholesteryl Ester Transfer Protein (CETP) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Organization of the human cholesteryl ester transfer protein gene."Biochemistry 29:1372-1376(1990) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  8. "Cholesteryl ester transfer proteins from different species do not have equivalent activities."J. Lipid Res. 55:258-265(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules." Nat. Struct. Mol. Biol. 14:106-113(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation."N. Engl. J. Med. 323:1234-1238(1990) [PubMed] [Europe PMC] [Abstract]
  11. "A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins."J. Clin. Invest. 92:2060-2064(1993) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  13. ErratumNat. Genet. 23:373-373(1999)
  14. "Two novel missense mutations in the CETP gene in Japanese hyperalphalipoproteinemic subjects: high-throughput assay by Invader assay."J. Lipid Res. 43:1011-1018(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors."Hum. Mol. Genet. 12:2733-2743(2003) [PubMed] [Europe PMC] [Abstract]