Pregnancy Associated Plasma Protein A (PAPPA)
[Edit]PAPP-A; PAPA; ASBABP2; DIPLA1; IGFBP-4ase; PAPPA1; Pappalysin 1; Insulin-Like Growth Factor Binding Protein-4 Protease; Differentially Placenta 1 Expressed Protein
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PAPP-A is a large heterottetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome. a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes). For example, low PAPPA may be seen in prenatal screening for Down syndrome.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA800Mu01 | Recombinant Pregnancy Associated Plasma Protein A (PAPPA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA800Mu02 | Recombinant Pregnancy Associated Plasma Protein A (PAPPA) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA800Mu01 | Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) | WB; IHC; ICC; IP. |
| LAA800Mu81 | FITC-Linked Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) | WB; IHC; ICC; IF. | |
| LAA800Mu71 | Biotin-Linked Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) | WB; IHC; ICC. | |
| PAA800Mu02 | Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA800Mu | ELISA Kit for Pregnancy Associated Plasma Protein A (PAPPA) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA800Ra01 | Recombinant Pregnancy Associated Plasma Protein A (PAPPA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Pregnancy Associated Plasma Protein A (PAPPA) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Pregnancy Associated Plasma Protein A (PAPPA) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pregnancy Associated Plasma Protein A (PAPPA) | ELISA Kit Customized Service Offer |
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- "Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A."FEBS Lett. 504:36-40(2001) [PubMed] [Europe PMC] [Abstract]
- "Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene."Am. J. Hum. Genet. 70:663-672(2002) [PubMed] [Europe PMC] [Abstract]