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Angiotensinogen (AGT)

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ANHU; SERPINA8; Angiotensin; Renin Substrate; Serpin Peptidase Inhibitor,Clade A,Member 8(Alpha-1 Antiproteinase,Antitrypsin)

Angiotensinogen (AGT)
CCC A797
HGNC 333
MGI 87963
PubMed 11181790
RGD 2069
UniProt P01019
Wiki Angiotensin
Angiotensinogen is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. It is a member of the serpin family, although it is not known to inhibit other enzymes, unlike most serpins. Plasma angiotensinogen levels are increased by plasma corticosteroid, estrogen, thyroid hormone, and angiotensin II levels.
Angiotensin is formed from a precursor, angiotensinogen, which is produced by the liver and found in the alpha-globulin fraction of plasma. The lowering of blood pressure is a stimulus to secretion of renin by the kidney into the blood. Renin cleaves from angiotensinogen a terminal decapeptide, angiotensin I. This is further altered by the enzymatic removal of a dipeptide to form angiotensin II.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA797Hu01 Recombinant Angiotensinogen (AGT) Positive Control; Immunogen; SDS-PAGE; WB.
RPA797Hu02 Recombinant Angiotensinogen (AGT) Positive Control; Immunogen; SDS-PAGE; WB.
EPA797Hu61 Eukaryotic Angiotensinogen (AGT) Positive Control; Immunogen; SDS-PAGE; WB.
APA797Hu61 Active Angiotensinogen (AGT) Cell culture; Activity Assays.
Antibodies PAA797Hu01 Polyclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
MAA797Hu22 Monoclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
PAA797Hu02 Polyclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
Assay Kits SEA797Hu ELISA Kit for Angiotensinogen (AGT) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA797Hu CLIA Kit for Angiotensinogen (AGT) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA797Mu01 Recombinant Angiotensinogen (AGT) Positive Control; Immunogen; SDS-PAGE; WB.
RPA797Mu02 Recombinant Angiotensinogen (AGT) Positive Control; Immunogen; SDS-PAGE; WB.
EPA797Mu61 Eukaryotic Angiotensinogen (AGT) Positive Control; Immunogen; SDS-PAGE; WB.
APA797Mu61 Active Angiotensinogen (AGT) Cell culture; Activity Assays.
Antibodies PAA797Mu01 Polyclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
LAA797Mu71 Biotin-Linked Polyclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC.
LAA797Mu81 FITC-Linked Polyclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IF.
PAA797Mu02 Polyclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
Assay Kits SEA797Mu ELISA Kit for Angiotensinogen (AGT) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA797Mu CLIA Kit for Angiotensinogen (AGT) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA797Ra01 Recombinant Angiotensinogen (AGT) Positive Control; Immunogen; SDS-PAGE; WB.
EPA797Ra61 Eukaryotic Angiotensinogen (AGT) Positive Control; Immunogen; SDS-PAGE; WB.
APA797Ra61 Active Angiotensinogen (AGT) Cell culture; Activity Assays.
Antibodies PAA797Ra01 Polyclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
LAA797Ra71 Biotin-Linked Polyclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC.
LAA797Ra81 FITC-Linked Polyclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IF.
MAA797Ra21 Monoclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
MAA797Ra26 Monoclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
MAA797Ra22 Monoclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
MAA797Ra23 Monoclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
MAA797Ra24 Monoclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
MAA797Ra27 Monoclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
MAA797Ra25 Monoclonal Antibody to Angiotensinogen (AGT) WB; IHC; ICC; IP.
Assay Kits SEA797Ra ELISA Kit for Angiotensinogen (AGT) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence."Biochemistry 23:3603-3609(1984) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of human angiotensinogen gene."DNA 8:87-99(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and expression of the human angiotensinogen gene. Identification of a unique and highly active promoter."J. Biol. Chem. 265:7576-7582(1990) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning of human angiotensinogen cDNA and evidence for the presence of its mRNA in rat heart."Circ. Res. 60:786-790(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Tissue specific hormonal regulation of the rat angiotensinogen gene expression."Arch. Biochem. Biophys. 254:642-646(1987) [PubMed] [Europe PMC] [Abstract]
  7. "The amino terminal amino acid sequence of human angiotensinogen."Biochem. Biophys. Res. Commun. 99:1311-1315(1981) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma."J. Biol. Chem. 270:13645-13651(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Enzymatic degradation and electrophoresis of human angiotensin I."Biochim. Biophys. Acta 168:106-112(1968) [PubMed] [Europe PMC] [Abstract]
  10. "Processing of rat and human angiotensinogen precursors by microsomal membranes."Mol. Cell. Endocrinol. 43:31-40(1985) [PubMed] [Europe PMC] [Abstract]
  11. "Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system."Circ. Res. 36:38-48(1975) [PubMed] [Europe PMC] [Abstract]
  12. "The renin-angiotensin-aldosterone system: a specific target for hypertension management."Am. J. Hypertens. 12:205S-213S(1999) [PubMed] [Europe PMC] [Abstract]
  13. "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9."Circ. Res. 87:E1-E9(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase."J. Biol. Chem. 277:14838-14843(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism."Biochem. J. 383:45-51(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Mass-spectrometric identification of a novel angiotensin peptide in human plasma."Arterioscler. Thromb. Vasc. Biol. 27:297-302(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Renin-angiotensin system revisited."J. Intern. Med. 264:224-236(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "The octapeptide angiotensin II adopts a well-defined structure in a phospholipid environment."Eur. J. Biochem. 251:448-453(1998) [PubMed] [Europe PMC] [Abstract]
  23. "Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship."Eur. J. Biochem. 270:2163-2173(2003) [PubMed] [Europe PMC] [Abstract]
  24. "A redox switch in angiotensinogen modulates angiotensin release."Nature 468:108-111(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Molecular basis of human hypertension: role of angiotensinogen."Cell 71:169-180(1992) [PubMed] [Europe PMC] [Abstract]
  26. "A molecular variant of angiotensinogen associated with preeclampsia."Nat. Genet. 4:59-61(1993) [PubMed] [Europe PMC] [Abstract]
  27. "Detection and characterization of new mutations in the human angiotensinogen gene (AGT)."Hum. Genet. 96:110-112(1995) [PubMed] [Europe PMC] [Abstract]
  28. "A mutation of angiotensinogen in a patient with preeclampsia leads to altered kinetics of the renin-angiotensin system."J. Biol. Chem. 270:11430-11436(1995) [PubMed] [Europe PMC] [Abstract]
  29. "The natural mutation Y248C of human angiotensinogen leads to abnormal glycosylation and altered immunological recognition of the protein."J. Biol. Chem. 271:9838-9844(1996) [PubMed] [Europe PMC] [Abstract]
  30. "Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis."Nat. Genet. 37:964-968(2005) [PubMed] [Europe PMC] [Abstract]