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Toll Like Receptor 4 (TLR4)

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CD284; TOLL; HToll

Toll Like Receptor 4 (TLR4)
CCC A753
HGNC 11850
MGI 96824
PubMed 10835634
RGD 3870
UniProt O00206
Wiki TLR_4

TLR 4 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA753Hu01 Recombinant Toll Like Receptor 4 (TLR4) Positive Control; Immunogen; SDS-PAGE; WB.
CPA753Hu21 OVA Conjugated Toll Like Receptor 4 (TLR4) Immunogen; SDS-PAGE; WB.
RPA753Hu02 Recombinant Toll Like Receptor 4 (TLR4) Positive Control; Immunogen; SDS-PAGE; WB.
APA753Hu01 Active Toll Like Receptor 4 (TLR4) Cell culture; Activity Assays.
APA753Hu02 Active Toll Like Receptor 4 (TLR4) Cell culture; Activity Assays.
RPA753Hu03 Recombinant Toll Like Receptor 4 (TLR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA753Hu01 Polyclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IP; FCM
MAA753Hu22 Monoclonal Antibody to Toll Like Receptor 4 (TLR4) WB
LAA753Hu71 Biotin-Linked Polyclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC.
PAA753Hu08 Polyclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IP.
PAA753Hu02 Polyclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IP.
LAA753Hu72 Biotin-Linked Monoclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC.
MAA753Hu21 Monoclonal Antibody to Toll Like Receptor 4 (TLR4) WB
MAA753Hu24 Monoclonal Antibody to Toll Like Receptor 4 (TLR4) WB
MAA753Hu23 Monoclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IP.
MAA753Hu25 Monoclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IP.
Assay Kits SEA753Hu ELISA Kit for Toll Like Receptor 4 (TLR4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA753Mu01 Recombinant Toll Like Receptor 4 (TLR4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA753Mu02 Recombinant Toll Like Receptor 4 (TLR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA753Mu01 Polyclonal Antibody to Toll Like Receptor 4 (TLR4) WB
LAA753Mu71 Biotin-Linked Polyclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC.
LAA753Mu81 FITC-Linked Polyclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IF.
PAA753Mu02 Polyclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IP.
Assay Kits SEA753Mu ELISA Kit for Toll Like Receptor 4 (TLR4) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA753Mu CLIA Kit for Toll Like Receptor 4 (TLR4) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA753Ra01 Recombinant Toll Like Receptor 4 (TLR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA753Ra01 Polyclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC
LAA753Ra71 Biotin-Linked Polyclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC.
LAA753Ra81 FITC-Linked Polyclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IF.
MAA753Ra21 Monoclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IP.
Assay Kits SEA753Ra ELISA Kit for Toll Like Receptor 4 (TLR4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Toll Like Receptor 4 (TLR4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Toll Like Receptor 4 (TLR4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Toll Like Receptor 4 (TLR4) Polyclonal Antibody Customized Service Offer
Assay Kits SEA753Po ELISA Kit for Toll Like Receptor 4 (TLR4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA753Bo01 Recombinant Toll Like Receptor 4 (TLR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA753Bo01 Polyclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IP.
MAA753Bo21 Monoclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IP.
Assay Kits SEA753Bo ELISA Kit for Toll Like Receptor 4 (TLR4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Capra hircus; Caprine (Goat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA753Cp01 Recombinant Toll Like Receptor 4 (TLR4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAA753Cp21 Monoclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IP.
MAA753Cp22 Monoclonal Antibody to Toll Like Receptor 4 (TLR4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Toll Like Receptor 4 (TLR4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Toll Like Receptor 4 (TLR4) ELISA Kit Customized Service Offer
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  2. "A family of human receptors structurally related to Drosophila Toll."Proc. Natl. Acad. Sci. U.S.A. 95:588-593(1998) [PubMed] [Europe PMC] [Abstract]
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  4. "TLR4 mutations are associated with endotoxin hyporesponsiveness in humans."Nat. Genet. 25:187-191(2000) [PubMed] [Europe PMC] [Abstract]
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  8. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis for signal transduction by the Toll/interleukin-1 receptor domains."Nature 408:111-115(2000) [PubMed] [Europe PMC] [Abstract]
  12. "MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor."J. Biol. Chem. 277:1845-1854(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B."J. Immunol. 173:3589-3593(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity."Circ. Res. 100:1589-1596(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."Nat. Commun. 1:79-79(2010) [PubMed] [Europe PMC] [Abstract]
  16. ErratumNat. Commun. 3:653-653(2012)
  17. "CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer."Nat. Immunol. 11:155-161(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel."Nat. Immunol. 11:814-819(2010) [PubMed] [Europe PMC] [Abstract]
  19. "MLK4 has negative effect on TLR4 signaling."Cell. Mol. Immunol. 9:27-33(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran."Cell 130:906-917(2007) [PubMed] [Europe PMC] [Abstract]
  21. "The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex."Nature 458:1191-1195(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein."PLoS ONE 7:E30929-E30929(2012) [PubMed] [Europe PMC] [Abstract]
  23. "Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans."Genetics 158:1657-1664(2001) [PubMed] [Europe PMC] [Abstract]
  24. "Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration."Hum. Mol. Genet. 14:1449-1455(2005) [PubMed] [Europe PMC] [Abstract]