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Cluster Of Differentiation 38 (CD38)

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cADPRH; ADPRC 1; c-ADPRH; T10; p45; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1

Cluster Of Differentiation 38 (CD38)
CCC A752
HGNC 1667
MGI 107474
PubMed 15078169
RGD 2303
UniProt P28907

CD38 (cluster of differentiation 38) is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4 , CD8 , B and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.In humans, the CD38 protein is encoded by the CD38 gene which located on chromosome 4. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+.The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.

 

 


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Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA752Hu01 Recombinant Cluster Of Differentiation 38 (CD38) Positive Control; Immunogen; SDS-PAGE; WB.
EPA752Hu61 Eukaryotic Cluster Of Differentiation 38 (CD38) Positive Control; Immunogen; SDS-PAGE; WB.
APA752Hu61 Active Cluster Of Differentiation 38 (CD38) Cell culture; Activity Assays.
Antibodies PAA752Hu01 Polyclonal Antibody to Cluster Of Differentiation 38 (CD38) WB; IHC; ICC; IP.
MAA752Hu23 Monoclonal Antibody to Cluster Of Differentiation 38 (CD38) WB; IHC; ICC; IP.
MAA752Hu24 Monoclonal Antibody to Cluster Of Differentiation 38 (CD38) WB; IHC; ICC; IP.
MAA752Hu25 Monoclonal Antibody to Cluster Of Differentiation 38 (CD38) WB; IHC; ICC; IP.
MAA752Hu21 Monoclonal Antibody to Cluster Of Differentiation 38 (CD38) WB; IHC; ICC; IP.
MAA752Hu22 Monoclonal Antibody to Cluster Of Differentiation 38 (CD38) WB; IHC; ICC; IP.
Assay Kits SEA752Hu ELISA Kit for Cluster Of Differentiation 38 (CD38) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA752Mu01 Recombinant Cluster Of Differentiation 38 (CD38) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA752Mu01 Polyclonal Antibody to Cluster Of Differentiation 38 (CD38) WB; IHC; ICC; IP.
LAA752Mu71 Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 38 (CD38) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 38 (CD38) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 38 (CD38) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA752Ra01 Recombinant Cluster Of Differentiation 38 (CD38) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA752Ra01 Polyclonal Antibody to Cluster Of Differentiation 38 (CD38) WB; IHC; ICC; IP.
MAA752Ra21 Monoclonal Antibody to Cluster Of Differentiation 38 (CD38) WB; IHC; ICC; IP.
Assay Kits SEA752Ra ELISA Kit for Cluster Of Differentiation 38 (CD38) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation."J. Immunol. 144:2811-2815(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing."Gene 186:285-292(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38."Trends Biochem. Sci. 17:495-495(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP."J. Biol. Chem. 268:26052-26054(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38."J. Biol. Chem. 269:28555-28557(1994) [PubMed] [Europe PMC] [Abstract]
  7. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  8. "NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases."Biochem. Biophys. Res. Commun. 345:573-580(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of human CD38 extracellular domain."Structure 13:1331-1339(2005) [PubMed] [Europe PMC] [Abstract]
  13. "A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro."Diabetologia 41:1024-1028(1998) [PubMed] [Europe PMC] [Abstract]