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Toll Like Receptor 9 (TLR9)

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CD289

Toll Like Receptor 9 (TLR9)
CCC A709
HGNC 15633
MGI 1932389
PubMed 15588423
RGD 631352
UniProt Q9NR96
Wiki TLR9
Toll-like receptors (TLRs) recognize microbial products and initiate a complex immune response designed to eliminate invading pathogens.
TLR9 is specialized to recognize microbial nucleic acids, and 1 factor enabling TLR9 to discriminate between self and foreign DNA is the presence of unmethylated CpG dinucleotides in bacterial DNA (Hasan et al., 2007).other TLR proteins, TLR9 contains extracellular leucine-rich repeats (LRRs) and a cytoplasmic toll/interleukin-1R (TIR) domain. It also has a signal peptide (residues 1 to 25) and a transmembrane domain (residues 819 to 836). Northern blot analysis of mouse tissues revealed highest Tlr9 expression in spleen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA709Hu01 Recombinant Toll Like Receptor 9 (TLR9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA709Hu01 Polyclonal Antibody to Toll Like Receptor 9 (TLR9) WB; IHC; ICC; IP.
MAA709Hu22 Monoclonal Antibody to Toll Like Receptor 9 (TLR9) WB; IHC; ICC; IP.
Assay Kits SEA709Hu ELISA Kit for Toll Like Receptor 9 (TLR9) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA709Hu CLIA Kit for Toll Like Receptor 9 (TLR9) Chemiluminescent immunoassay for Antigen Detection.
HEA709Hu High Sensitive ELISA Kit for Toll Like Receptor 9 (TLR9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA709Mu01 Recombinant Toll Like Receptor 9 (TLR9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA709Mu01 Polyclonal Antibody to Toll Like Receptor 9 (TLR9) WB; IHC; ICC; IP.
Assay Kits SEA709Mu ELISA Kit for Toll Like Receptor 9 (TLR9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA709Ra01 Recombinant Toll Like Receptor 9 (TLR9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA709Ra01 Polyclonal Antibody to Toll Like Receptor 9 (TLR9) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Toll Like Receptor 9 (TLR9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Toll Like Receptor 9 (TLR9) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA709Rb01 Recombinant Toll Like Receptor 9 (TLR9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA709Rb51 Polyclonal Antibody to Toll Like Receptor 9 (TLR9) WB; IHC; ICC; IP.
PAA709Rb01 Polyclonal Antibody to Toll Like Receptor 9 (TLR9) WB; IHC; ICC; IP.
Assay Kits SEA709Rb ELISA Kit for Toll Like Receptor 9 (TLR9) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Three novel mammalian Toll-like receptors: gene structure, expression, and evolution."Eur. Cytokine Netw. 11:362-371(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9."Eur. Cytokine Netw. 11:372-378(2000) [PubMed] [Europe PMC] [Abstract]
  3. "A Toll-like receptor recognizes bacterial DNA."Nature 408:740-745(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Natural selection in the TLR-related genes in the course of primate evolution."Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
  6. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells."J. Immunol. 167:3555-3558(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase."J. Biol. Chem. 282:36953-36960(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."Nat. Commun. 1:79-79(2010) [PubMed] [Europe PMC] [Abstract]
  11. ErratumNat. Commun. 3:653-653(2012)
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]